Bioinspired and self-restorable alginate-tyramine hydrogels with plasma reinforcement for arthritis treatment

Yu Ming Chen, Chin Chean Wong, Pei Wei Weng, Chih Wei Chiang, Po Yen Lin, Po Wei Lee, Pei Ru Jheng, Ping Chien Hao, Yan Ting Chen, Er Chen Cho, Er Yuan Chuang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Long-standing administration of disease-modifying antirheumatic drugs confirms their clinical value for managing rheumatoid arthritis (RA). Nevertheless, there are emergent worries over unwanted adverse risks of systemic drug administration. Hence, a novel strategy that can be used in a drug-free manner while diminishing side effects is immediately needed, but challenges persist in the therapy for RA. To this end, herein we conjugated tyramine (TYR) with alginate (ALG) to form ALG-TYR and then treated it for 5 min with oxygen plasma (ALG-TYR + P/5 min). It was shown that the ALG-TYR + P/5 min hydrogel exhibited favorable viscoelastic, morphological, mechanical, biocompatible, and cellular heat-shock protein amplification behaviors. A thorough physical and structural analysis was conducted on the ALG-TYR + P/5 min hydrogel, revealing favorable physical characteristics and uniform porous structural features within the hydrogel. Moreover, ALG-TYR + P/5 min not only effectively inhibited inflammation of RA but also potentially regulated lesion immunity. Once ALG-TYR + P/5 min was intra-articularly administered to joints of rats with zymosan-induced arthritis, we observed that ALG-TYR + P/5 min could ameliorate syndromes of RA joint. This bioinspired and self-restorable ALG-TYR + P/5 min hydrogel can thus serve as a promising system to provide prospective outcomes to potentiate RA therapy.

Original languageEnglish
Article number126105
JournalInternational Journal of Biological Macromolecules
Volume250
DOIs
Publication statusPublished - Oct 1 2023

Keywords

  • Arthritis treatment
  • Immunomodulation
  • Self-restorable alginate-tyramine hydrogel

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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