Biofabrication of bone tissue: Approaches, challenges and translation for bone regeneration

Daniel Tang, Rahul S. Tare, Liang Yo Yang, David F. Williams, Keng Liang Ou, Richard O C Oreffo

Research output: Contribution to journalReview articlepeer-review

489 Citations (Scopus)


The rising incidence of bone disorders has resulted in the need for more effective therapies to meet this demand, exacerbated by an increasing ageing population. Bone tissue engineering is seen as a means of developing alternatives to conventional bone grafts for repairing or reconstructing bone defects by combining biomaterials, cells and signalling factors. However, skeletal tissue engineering has not yet achieved full translation into clinical practice as a consequence of several challenges. The use of additive manufacturing techniques for bone biofabrication is seen as a potential solution, with its inherent capability for reproducibility, accuracy and customisation of scaffolds as well as cell and signalling factor delivery. This review highlights the current research in bone biofabrication, the necessary factors for successful bone biofabrication, in addition to the current limitations affecting biofabrication, some of which are a consequence of the limitations of the additive manufacturing technology itself.

Original languageEnglish
Pages (from-to)363-382
Number of pages20
Publication statusPublished - Mar 1 2016


  • Angiogenesis
  • Biofabrication
  • Bone tissue engineering
  • Osteogenesis
  • Skeletal stem cell
  • Tissue regeneration

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials


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