TY - JOUR
T1 - Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites
AU - Choi, Charles J.
AU - Wu, Hsin Yu
AU - George, Sherine
AU - Weyhenmeyer, Jonathan
AU - Cunningham, Brian T.
PY - 2012/2/7
Y1 - 2012/2/7
N2 - In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.
AB - In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.
UR - http://www.scopus.com/inward/record.url?scp=84862946291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862946291&partnerID=8YFLogxK
U2 - 10.1039/c2lc20586f
DO - 10.1039/c2lc20586f
M3 - Article
C2 - 22159459
AN - SCOPUS:84862946291
SN - 1473-0197
VL - 12
SP - 574
EP - 581
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
IS - 3
ER -