Bioactivity and bone cell formation with poly-ε-caprolactone/bioceramic 3D porous scaffolds

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


This study applied poly-ε-caprolactone (PCL), a biomedical ceramic powder as an additive (nano-hydroxyapatite (nHA) or β-tricalcium diphosphate (β-TCP)), and sodium chloride (NaCl) and ammonium bicarbonate ((NH4)HCO3) as porogens; these stuffs were used as scaffold materials. An improved solvent-casting/particulate-leaching method was utilized to fabricate 3D porous scaffolds. In this study we examined the physical properties (elastic modulus, porosity, and contact angle) and degradation properties (weight loss and pH value) of the 3D porous scaffolds. Both nHA and β-TCP improved the mechanical properties (elastic modulus) of the 3D porous scaf-folds. The elastic modulus (0.15~1.865 GPa) of the various composite scaffolds matched that of human cancellous bone (0.1~4.5 GPa). Osteoblast-like (MG63) cells were cultured, a microculture te-trazolium test (MTT) was conducted and alkaline phosphatase (ALP) activity of the 3D porous scaffolds was determined. Experimental results indicated that both nHA and β-TCP powder improved the hydrophilic properties of the scaffolds. The degradation rate of the scaffolds was accelerated by adding nHA or β-TCP. The MTT and ALP activity tests indicated that the scaffolds with a high ratio of nHA or β-TCP had excellent properties of in vitro biocompatibility (cell attachment and prolifer-ation).

Original languageEnglish
Article number2718
Issue number16
Publication statusPublished - Aug 2021


  • 3D composite scaffold
  • Bioceramic
  • Biocompatibility
  • Improved solvent-casting/particulate-leaching
  • Physical and degradation properties

ASJC Scopus subject areas

  • General Chemistry
  • Polymers and Plastics


Dive into the research topics of 'Bioactivity and bone cell formation with poly-ε-caprolactone/bioceramic 3D porous scaffolds'. Together they form a unique fingerprint.

Cite this