Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice

Yu Tang Tung; Chi Chang Huang; Shang Tse Ho; Yueh Hsiung Kuo; Chi Chen Lin; Chien Tsong Lin; Jyh Horng Wu

doi:10.1021/jf2018935

Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice

Yu Tang Tung, Chi Chang Huang, Shang Tse Ho, Yueh Hsiung Kuo, Chi Chen Lin, Chien Tsong Lin, Jyh Horng Wu

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.

Original language	English
Pages (from-to)	8117-8123
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	59
Issue number	15
DOIs	https://doi.org/10.1021/jf2018935
Publication status	Published - Aug 10 2011
Externally published	Yes

Keywords

acute liver failure (ALF)
Cinnamomum osmophloeum
essential oil
hepatoprotection
lipopolysaccharide/D- galactosamine (LPS/D-GalN)

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jf2018935

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Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice. / Tung, Yu Tang; Huang, Chi Chang; Ho, Shang Tse et al.
In: Journal of Agricultural and Food Chemistry, Vol. 59, No. 15, 10.08.2011, p. 8117-8123.

Research output: Contribution to journal › Article › peer-review

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abstract = "The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.",

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AU - Kuo, Yueh Hsiung

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AB - The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.

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Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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