Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies

Yen-Chen Chen; Yun-Ching Chen; Wen-Dar Lin; Chung-Der Hsiao; Hung-Wen Chiu; Jan-Ming Ho

doi:10.5402/2012/139842

Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies

Yen-Chen Chen, Yun-Ching Chen, Wen-Dar Lin, Chung-Der Hsiao, Hung-Wen Chiu, Jan-Ming Ho

Research output: Contribution to journal › Article › peer-review

Abstract

In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.

Original language	English
Pages (from-to)	139842
Journal	ISRN bioinformatics
Volume	2012
DOIs	https://doi.org/10.5402/2012/139842
Publication status	Published - 2012

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Journal Article

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10.5402/2012/139842

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abstract = "In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.",

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AU - Chen, Yen-Chen

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AU - Hsiao, Chung-Der

AU - Chiu, Hung-Wen

AU - Ho, Jan-Ming

PY - 2012

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AB - In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.

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JO - ISRN bioinformatics

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ER -

Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies

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