Autophagy regulates ageing in C. elegans

Eszter S. Hars; Haiyan Qi; Alexey G. Ryazanov; Shengkan Jin; Li Cai; Chengcheng Hu; Leroy F. Liu

doi:10.4161/auto.3636

Autophagy regulates ageing in C. elegans

Eszter S. Hars, Haiyan Qi, Alexey G. Ryazanov, Shengkan Jin, Li Cai, Chengcheng Hu, Leroy F. Liu

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

Abstract

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	Autophagy
Volume	3
Issue number	2
DOIs	https://doi.org/10.4161/auto.3636
Publication status	Published - 2007
Externally published	Yes

Keywords

Ageing
Autophagy
Lifespan
atg-12
atg-7
bec-1
daf-2

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/auto.3636

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@article{a940c47b578c489783c98b4791959f22,

title = "Autophagy regulates ageing in C. elegans",

abstract = "The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.",

keywords = "Ageing, Autophagy, Lifespan, atg-12, atg-7, bec-1, daf-2",

author = "Hars, \{Eszter S.\} and Haiyan Qi and Ryazanov, \{Alexey G.\} and Shengkan Jin and Li Cai and Chengcheng Hu and Liu, \{Leroy F.\}",

note = "Funding Information: dsRNA. {\textcopyright}This work was supported by NIH We also measured lifespan of the offspring (F1) since a longer exposure to dsRNA is shown).",

year = "2007",

doi = "10.4161/auto.3636",

language = "English",

volume = "3",

pages = "93--95",

journal = "Autophagy",

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publisher = "Taylor and Francis Ltd.",

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T1 - Autophagy regulates ageing in C. elegans

AU - Hars, Eszter S.

AU - Qi, Haiyan

AU - Ryazanov, Alexey G.

AU - Jin, Shengkan

AU - Cai, Li

AU - Hu, Chengcheng

AU - Liu, Leroy F.

N1 - Funding Information: dsRNA. ©This work was supported by NIH We also measured lifespan of the offspring (F1) since a longer exposure to dsRNA is shown).

PY - 2007

Y1 - 2007

N2 - The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

AB - The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

KW - Ageing

KW - Autophagy

KW - Lifespan

KW - atg-12

KW - atg-7

KW - bec-1

KW - daf-2

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VL - 3

SP - 93

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JO - Autophagy

JF - Autophagy

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ER -

Autophagy regulates ageing in C. elegans

Abstract

Keywords

ASJC Scopus subject areas

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