Autophagy facilitates an IFN-γ response and signal transduction

Yu-Ping Chang, Chia-Ling Chen, Su-O. Chen, Yee-Shin Lin, Cheng-Chieh Tsai, Wei-Ching Huang, Chi-Yun Wang, Chia-Yuan Hsieh, Pui-Ching Choi, Chiou Feng Lin

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-γ, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-γ response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes.

Original languageEnglish
Pages (from-to)888-894
Number of pages7
JournalMicrobes and Infection
Issue number11
Publication statusPublished - Oct 2011


  • Autophagy
  • IFN-γ
  • Immune escape
  • Inflammation
  • Microbe
  • Signal transduction

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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