Autoimmunity in dengue virus infection

Chiou Feng Lin; Huan Yao Lei; Ching Chuan Lui; Hsiao Sheng Lui; Trai Ming Yeh; Shun Hua Chen; Yee Shin Lin

Autoimmunity in dengue virus infection

Chiou Feng Lin, Huan Yao Lei, Ching Chuan Lui, Hsiao Sheng Lui, Trai Ming Yeh, Shun Hua Chen, Yee Shin Lin

Research output: Contribution to journal › Article › peer-review

Abstract

Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Dengue Bulletin
Volume	28
Publication status	Published - Dec 2004
Externally published	Yes

Keywords

Autoantibody
Dengue haemorrhagic fever
Dengue virus serotype
Endothelial cells

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Autoimmunity in dengue virus infection",

abstract = "Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.",

keywords = "Autoantibody, Dengue haemorrhagic fever, Dengue virus serotype, Endothelial cells",

author = "Lin, {Chiou Feng} and Lei, {Huan Yao} and Lui, {Ching Chuan} and Lui, {Hsiao Sheng} and Yeh, {Trai Ming} and Chen, {Shun Hua} and Lin, {Yee Shin}",

year = "2004",

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language = "English",

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pages = "51--57",

journal = "Dengue Bulletin",

issn = "1020-895X",

publisher = "World Health Organization",

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TY - JOUR

T1 - Autoimmunity in dengue virus infection

AU - Lin, Chiou Feng

AU - Lei, Huan Yao

AU - Lui, Ching Chuan

AU - Lui, Hsiao Sheng

AU - Yeh, Trai Ming

AU - Chen, Shun Hua

AU - Lin, Yee Shin

PY - 2004/12

Y1 - 2004/12

N2 - Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.

AB - Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.

KW - Autoantibody

KW - Dengue haemorrhagic fever

KW - Dengue virus serotype

KW - Endothelial cells

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M3 - Article

AN - SCOPUS:19044364579

SN - 1020-895X

VL - 28

SP - 51

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JO - Dengue Bulletin

JF - Dengue Bulletin

ER -

Autoimmunity in dengue virus infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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