TY - JOUR
T1 - Autoimmune pathogenesis in dengue virus infection
AU - Lin, Chiou Feng
AU - Wan, Shu Wen
AU - Cheng, Hsien Jen
AU - Lei, Huan Yao
AU - Lin, Yee Shin
PY - 2006
Y1 - 2006
N2 - The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved. Patients with DHF/DSS are characterized by several manifestations, including severe thrombocytopenia, vascular leakage, and hepatomegaly. In addition to the effect of virus load and virus variation, abnormal immune responses of the host after DV infection may also account for the progression of DHF/DSS. Actually, viral autoimmunity is involved in the pathogenesis of numerous viral infections, such as human immunodeficiency virus, human hepatitis C virus, human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, and DV. In this review, we discuss the implications of autoimmunity in dengue pathogenesis. Antibodies directed against DV noiistructural protein 1 (NS1) showed cross-reactivity with human platelets and endothelial cells, which lead to platelet and endothelial' cell damage and inflammatory activation. Based on these findings, we hypothesize that anti-BV NS1 is involved in the pathogenesis of DF and DHF/DSS, and this may provide important information in dengue vaccine development.
AB - The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved. Patients with DHF/DSS are characterized by several manifestations, including severe thrombocytopenia, vascular leakage, and hepatomegaly. In addition to the effect of virus load and virus variation, abnormal immune responses of the host after DV infection may also account for the progression of DHF/DSS. Actually, viral autoimmunity is involved in the pathogenesis of numerous viral infections, such as human immunodeficiency virus, human hepatitis C virus, human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, and DV. In this review, we discuss the implications of autoimmunity in dengue pathogenesis. Antibodies directed against DV noiistructural protein 1 (NS1) showed cross-reactivity with human platelets and endothelial cells, which lead to platelet and endothelial' cell damage and inflammatory activation. Based on these findings, we hypothesize that anti-BV NS1 is involved in the pathogenesis of DF and DHF/DSS, and this may provide important information in dengue vaccine development.
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U2 - 10.1089/vim.2006.19.127
DO - 10.1089/vim.2006.19.127
M3 - Review article
C2 - 16817755
AN - SCOPUS:33745882654
SN - 0882-8245
VL - 19
SP - 127
EP - 132
JO - Viral Immunology
JF - Viral Immunology
IS - 2
ER -
