Autoimmune pathogenesis in dengue virus infection

Chiou Feng Lin, Shu Wen Wan, Hsien Jen Cheng, Huan Yao Lei, Yee Shin Lin

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)


The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved. Patients with DHF/DSS are characterized by several manifestations, including severe thrombocytopenia, vascular leakage, and hepatomegaly. In addition to the effect of virus load and virus variation, abnormal immune responses of the host after DV infection may also account for the progression of DHF/DSS. Actually, viral autoimmunity is involved in the pathogenesis of numerous viral infections, such as human immunodeficiency virus, human hepatitis C virus, human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, and DV. In this review, we discuss the implications of autoimmunity in dengue pathogenesis. Antibodies directed against DV noiistructural protein 1 (NS1) showed cross-reactivity with human platelets and endothelial cells, which lead to platelet and endothelial' cell damage and inflammatory activation. Based on these findings, we hypothesize that anti-BV NS1 is involved in the pathogenesis of DF and DHF/DSS, and this may provide important information in dengue vaccine development.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalViral Immunology
Issue number2
Publication statusPublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology


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