Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai; Susumu Otsuka; Jihwan Myung; Toru Takumi

doi:10.1007/s11427-015-4891-7

Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai, Susumu Otsuka, Jihwan Myung, Toru Takumi

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

Original language	English
Pages (from-to)	976-984
Number of pages	9
Journal	Science China Life Sciences
Volume	58
Issue number	10
DOIs	https://doi.org/10.1007/s11427-015-4891-7
Publication status	Published - Oct 1 2015
Externally published	Yes

Keywords

ASD model mouse
copy number variations
DNA methylation
histone modification

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Environmental Science
General Agricultural and Biological Sciences

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10.1007/s11427-015-4891-7

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abstract = "Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.",

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AU - Nakai, Nobuhiro

AU - Otsuka, Susumu

AU - Myung, Jihwan

AU - Takumi, Toru

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

AB - Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

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KW - copy number variations

KW - DNA methylation

KW - histone modification

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Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Abstract

Keywords

ASJC Scopus subject areas

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