Attenuation of Chronic Stress-Induced Depressive-like Symptoms by Fish Oil via Alleviating Neuroinflammation and Impaired Tryptophan Metabolism in Aging Rats

Te Hsuan Tung, Wen De Lai, Hsiu Chuan Lee, Kuan Pin Su, Binar Panunggal, Shih Yi Huang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The prevalence of depression is increasing, and geriatric depression, in particular, is difficult to recognize and treat. Depression in older adults is often accompanied by neuroinflammation in the central nervous system (CNS). Neuroinflammation affects the brain’s physiological and immune functions through several pathways and induces depressive symptoms. This study investigated the relationship among depression, neuroinflammation, and fish oil supplementation. Thirty-six male Sprague-Dawley rats were used in an aging-related depression animal model to simulate geriatric depression. Cognitive function, depressive-like symptoms, peripheral nervous system and CNS inflammation status, and the tryptophan-related metabolic pathway were analyzed. The geriatric depression animal model was associated with depressive-like behaviors and cognitive impairment. The integrity of the blood-brain barrier was compromised, resulting in increased expression of ionized calcium-binding adapter molecule 1 and the glial fibrillary acidic protein in the brain, indicating increased neuroinflammation. Tryptophan metabolism was also negatively affected. The geriatric-depressive-like rats had high levels of neurotoxic 5-hydroxyindoleacetic acid and kynurenine in their hippocampus. Fish oil intake improved depressive-like symptoms and cognitive impairment, reduced proinflammatory cytokine expression, activated the brain’s glial cells, and increased the interleukin-10 level in the prefrontal cortex. Thus, fish oil intervention could ameliorate abnormal neurobehaviors and neuroinflammation and elevate the serotonin level in the hippocampus.

Original languageEnglish
Pages (from-to)14550-14561
Number of pages12
JournalJournal of Agricultural and Food Chemistry
Volume71
Issue number40
DOIs
Publication statusAccepted/In press - 2023

Keywords

  • cognition
  • fish oil
  • geriatric depression
  • glial cell
  • kynurenine pathway

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences

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