Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis

G. Kevin Hyde, S. Michael Stewart, Giovanna Scarel, Gregory N. Parsons, Chun Che Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su, Nancy A. Monteiro-Riviere, Roger J. Narayan

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


TiO2 films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO2 films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in agreement with literature results. The TiO2 films were shown to profoundly alter the water contact angle values of cellulose in a manner dependent upon processing characteristics. Higher amounts of protein adsorption indicated by blurry areas on images generated by scanning electron microscopy were noted on TiO2-coated cellulose acetate than on uncoated cellulose acetate. These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials.

Original languageEnglish
Pages (from-to)213-223
Number of pages11
JournalBiotechnology Journal
Issue number2
Publication statusPublished - Feb 2011


  • Biomaterials
  • Cellulose
  • Hemocompatibility
  • Hemostatic agent
  • Titanium oxide

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Molecular Medicine


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