Atomic layer deposition-based functionalization of materials for medical and environmental health applications

Roger J. Narayan, Shashishekar P. Adiga, Michael J. Pellin, Larry A. Curtiss, Alexander J. Hryn, Shane Stafslien, Bret Chisholm, Chun Che Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su, Chunming Jin, Junping Zhang, Nancy A. Monteiro-Riviere, Jeffrey W. Elam

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Nanoporous alumina membranes exhibit high pore densities, well-controlled and uniform pore sizes, as well as straight pores. Owing to these unusual properties, nanoporous alumina membranes are currently being considered for use in implantable sensor membranes and water purification membranes. Atomic layer deposition is a thin-film growth process that may be used to modify the pore size in a nanoporous alumina membrane while retaining a narrow pore distribution. In addition, films deposited by means of atomic layer deposition may impart improved biological functionality to nanoporous alumina membranes. In this study, zinc oxide coatings and platinum coatings were deposited on nanoporous alumina membranes by means of atomic layer deposition. PEGylated nanoporous alumina membranes were prepared by self-assembly of 1-mercaptoundec-11-yl hexa(ethylene glycol) on platinum-coated nanoporous alumina membranes. The pores of the PEGylated nanoporous alumina membranes remainedfree of fouling after exposure to human platelet-rich plasma; protein adsorption, fibrin networks and platelet aggregation were not observed on the coated membrane surface. Zinc oxide-coated nanoporous alumina membranes demonstrated activity against two waterborne pathogens, Escherichia coli and Staphylococcus aureus. The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications.

Original languageEnglish
Pages (from-to)2033-2064
Number of pages32
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number1917
Publication statusPublished - Apr 28 2010


  • Antimicrobial; antifouling
  • Atomic layer deposition
  • Nanoporous alumina
  • Self-assembly

ASJC Scopus subject areas

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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