TY - JOUR
T1 - Atomic layer deposition-based functionalization of materials for medical and environmental health applications
AU - Narayan, Roger J.
AU - Adiga, Shashishekar P.
AU - Pellin, Michael J.
AU - Curtiss, Larry A.
AU - Hryn, Alexander J.
AU - Stafslien, Shane
AU - Chisholm, Bret
AU - Shih, Chun Che
AU - Shih, Chun Ming
AU - Lin, Shing Jong
AU - Su, Yea Yang
AU - Jin, Chunming
AU - Zhang, Junping
AU - Monteiro-Riviere, Nancy A.
AU - Elam, Jeffrey W.
PY - 2010/4/28
Y1 - 2010/4/28
N2 - Nanoporous alumina membranes exhibit high pore densities, well-controlled and uniform pore sizes, as well as straight pores. Owing to these unusual properties, nanoporous alumina membranes are currently being considered for use in implantable sensor membranes and water purification membranes. Atomic layer deposition is a thin-film growth process that may be used to modify the pore size in a nanoporous alumina membrane while retaining a narrow pore distribution. In addition, films deposited by means of atomic layer deposition may impart improved biological functionality to nanoporous alumina membranes. In this study, zinc oxide coatings and platinum coatings were deposited on nanoporous alumina membranes by means of atomic layer deposition. PEGylated nanoporous alumina membranes were prepared by self-assembly of 1-mercaptoundec-11-yl hexa(ethylene glycol) on platinum-coated nanoporous alumina membranes. The pores of the PEGylated nanoporous alumina membranes remainedfree of fouling after exposure to human platelet-rich plasma; protein adsorption, fibrin networks and platelet aggregation were not observed on the coated membrane surface. Zinc oxide-coated nanoporous alumina membranes demonstrated activity against two waterborne pathogens, Escherichia coli and Staphylococcus aureus. The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications.
AB - Nanoporous alumina membranes exhibit high pore densities, well-controlled and uniform pore sizes, as well as straight pores. Owing to these unusual properties, nanoporous alumina membranes are currently being considered for use in implantable sensor membranes and water purification membranes. Atomic layer deposition is a thin-film growth process that may be used to modify the pore size in a nanoporous alumina membrane while retaining a narrow pore distribution. In addition, films deposited by means of atomic layer deposition may impart improved biological functionality to nanoporous alumina membranes. In this study, zinc oxide coatings and platinum coatings were deposited on nanoporous alumina membranes by means of atomic layer deposition. PEGylated nanoporous alumina membranes were prepared by self-assembly of 1-mercaptoundec-11-yl hexa(ethylene glycol) on platinum-coated nanoporous alumina membranes. The pores of the PEGylated nanoporous alumina membranes remainedfree of fouling after exposure to human platelet-rich plasma; protein adsorption, fibrin networks and platelet aggregation were not observed on the coated membrane surface. Zinc oxide-coated nanoporous alumina membranes demonstrated activity against two waterborne pathogens, Escherichia coli and Staphylococcus aureus. The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications.
KW - Antimicrobial; antifouling
KW - Atomic layer deposition
KW - Nanoporous alumina
KW - Self-assembly
UR - http://www.scopus.com/inward/record.url?scp=77951801404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951801404&partnerID=8YFLogxK
U2 - 10.1098/rsta.2010.0011
DO - 10.1098/rsta.2010.0011
M3 - Article
C2 - 20308114
AN - SCOPUS:77951801404
SN - 1364-503X
VL - 368
SP - 2033
EP - 2064
JO - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
IS - 1917
ER -