TY - JOUR
T1 - Asymmetric chitosan membranes prepared by dry/wet phase separation
T2 - A new type of wound dressing for controlled antibacterial release
AU - Mi, Fwu Long
AU - Wu, Yu Bey
AU - Shyu, Shin Shing
AU - Chao, An Chong
AU - Lai, Juin Yih
AU - Su, Chia Ching
N1 - Funding Information:
The authors wish to thank the National Science Council of Taiwan, ROC for the financial support of this project (NSC88-2216-E-012-001). They also would like to thank the Dr. J.Y. Schoung (Department of Plastic Surgery, Chinese Naval 806 Hospital) and Prof. R.N. Huang (Department of Life Science, National Central University) for their helps of in vitro antibacterial test and cytotoxicity study.
PY - 2003/2/15
Y1 - 2003/2/15
N2 - An AgSD-incorporated chitosan membrane with sustained antimicrobial capability has been developed by a dry/wet phase separation method to overcome current limitations in silver sulfadiazine (AgSD) cream for treating acute burn wounds. The asymmetric chitosan membrane consists of a dense skin and sponge-like porous layer, which can fit the requirements (oxygen permeability, controlled water vapor evaporation and the drainage of wound exudates) for this membrane to be used as a wound dressing. AgSD cream is a traditionally-used antibacterial for the prevention of wound infection; however, it has raised concern of potential silver toxicity. The asymmetric chitosan membrane acts as a rate-controlling wound dressing to incorporate AgSD, and release sulfadiazine and silver ions in a sustained way. The release mechanism depends on the mass-transfer resistance for the release of sulfadiazine and silver ions from the dense and sponge-like porous layers, and the chemical resistance for the interaction of silver ions with chitosan polymeric chains, respectively. The bacteria-cultures (Pseudomonas aeruginosa and Staphylococcus aureus) and cell-culture (3T3 fibroblasts) assay of the AgSD-incorporated asymmetric chitosan membrane showed prolonged antibacterial activity and decreased potential silver toxicity. The results in this study indicate that the new type of chitosan wound dressing incorporated with AgSD may be effective in the treatment of infected wounds.
AB - An AgSD-incorporated chitosan membrane with sustained antimicrobial capability has been developed by a dry/wet phase separation method to overcome current limitations in silver sulfadiazine (AgSD) cream for treating acute burn wounds. The asymmetric chitosan membrane consists of a dense skin and sponge-like porous layer, which can fit the requirements (oxygen permeability, controlled water vapor evaporation and the drainage of wound exudates) for this membrane to be used as a wound dressing. AgSD cream is a traditionally-used antibacterial for the prevention of wound infection; however, it has raised concern of potential silver toxicity. The asymmetric chitosan membrane acts as a rate-controlling wound dressing to incorporate AgSD, and release sulfadiazine and silver ions in a sustained way. The release mechanism depends on the mass-transfer resistance for the release of sulfadiazine and silver ions from the dense and sponge-like porous layers, and the chemical resistance for the interaction of silver ions with chitosan polymeric chains, respectively. The bacteria-cultures (Pseudomonas aeruginosa and Staphylococcus aureus) and cell-culture (3T3 fibroblasts) assay of the AgSD-incorporated asymmetric chitosan membrane showed prolonged antibacterial activity and decreased potential silver toxicity. The results in this study indicate that the new type of chitosan wound dressing incorporated with AgSD may be effective in the treatment of infected wounds.
KW - Asymmetric chitosan membrane
KW - Dry/wet phase separation
KW - Wound dressing
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U2 - 10.1016/S0376-7388(02)00505-7
DO - 10.1016/S0376-7388(02)00505-7
M3 - Article
AN - SCOPUS:0346034905
SN - 0376-7388
VL - 212
SP - 237
EP - 254
JO - Journal of Membrane Science
JF - Journal of Membrane Science
IS - 1-2
ER -