TY - JOUR
T1 - Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers
T2 - A Cohort Study
AU - Tung, Nguyen Thanh
AU - Lai, Ching Huang
AU - Pan, Chih Hong
AU - Chen, Wei Liang
AU - Wang, Chung Ching
AU - Liang, Che Wei
AU - Chien, Chi Yu
AU - Chuang, Kai Jen
AU - Thao, Huynh Nguyen Xuan
AU - Dung, Hoang Ba
AU - Thuy, Tran Phan Chung
AU - Chuang, Hsiao Chi
N1 - Funding Information:
This study was funded by the Ministry of Science and Technology of Taiwan (106-2314-B-016-015, 107-2314-B-016-045-MY3, 108-2314-B-038-093, and 109-2314-B-038-093-MY3). The authors wish to thank Ms. Yi-Syuan Lin, A-Chuan Ho, Shih-Ting Huang, Kai-Wei Cheng, and Mr. Huan-Wun Chen for technical assistance with this research.
Publisher Copyright:
© The Author(s).
PY - 2022/5
Y1 - 2022/5
N2 - The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the effects of welding fume PM2.5 deposition on fractional exhaled nitric oxide (FeNO), lung function, and blood pressure using generalized estimating equation models. Personal exposure to welding fumes was measured, and deposition fractions of inhaled welding fume PM2.5 in lung regions were estimated using multiple-path particle dosimetry. We observed the overall incidence rate of COPD to be 2.51 cases per 100 person-years. The incidence rate was higher in welding workers than in office workers and higher in non-smokers compared to smokers. In the overall cohort subjects, we observed that an increase in the interquartile range of PM2.5 was associated with a 1.618-ppb decrease in FeNO, a 0.115-L decrease in FVC, a 0.091-L decrease in FEV1, a 0.520% increase in the FEV1/FVC ratio, a 0.259-L s–1 decrease in PEF, a 0.096-L s–1 decrease in FEF25%-75%, a 0.215-L s–1 decrease in FEF25%, and a 0.114-L s–1 decrease in FEF50% (all p < 0.05). We observed that a 1-µg m–3 increase in PM2.5 deposition in lung regions (total lung, and head and nasal, tracheobronchial, and alveolar regions) was associated with decreases (β coefficients) in FeNO, FVC, FEV1, PEF, FEF25%-75%, FEF25%, and FEF50% (all p < 0.05). We observed that the absolute values of β coefficients decreased as follows: alveolar > head and nasal > tracheobronchial > total lung regions. Higher incidence rates of COPD were observed in non-smokers and welders, which associated with lung function declines due to PM2.5 exposure. Pulmonary effects by welding fume PM2.5 in occupational settings is an urgent occupational issue for worker health protection.
AB - The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the effects of welding fume PM2.5 deposition on fractional exhaled nitric oxide (FeNO), lung function, and blood pressure using generalized estimating equation models. Personal exposure to welding fumes was measured, and deposition fractions of inhaled welding fume PM2.5 in lung regions were estimated using multiple-path particle dosimetry. We observed the overall incidence rate of COPD to be 2.51 cases per 100 person-years. The incidence rate was higher in welding workers than in office workers and higher in non-smokers compared to smokers. In the overall cohort subjects, we observed that an increase in the interquartile range of PM2.5 was associated with a 1.618-ppb decrease in FeNO, a 0.115-L decrease in FVC, a 0.091-L decrease in FEV1, a 0.520% increase in the FEV1/FVC ratio, a 0.259-L s–1 decrease in PEF, a 0.096-L s–1 decrease in FEF25%-75%, a 0.215-L s–1 decrease in FEF25%, and a 0.114-L s–1 decrease in FEF50% (all p < 0.05). We observed that a 1-µg m–3 increase in PM2.5 deposition in lung regions (total lung, and head and nasal, tracheobronchial, and alveolar regions) was associated with decreases (β coefficients) in FeNO, FVC, FEV1, PEF, FEF25%-75%, FEF25%, and FEF50% (all p < 0.05). We observed that the absolute values of β coefficients decreased as follows: alveolar > head and nasal > tracheobronchial > total lung regions. Higher incidence rates of COPD were observed in non-smokers and welders, which associated with lung function declines due to PM2.5 exposure. Pulmonary effects by welding fume PM2.5 in occupational settings is an urgent occupational issue for worker health protection.
KW - Air pollution
KW - Alveoli
KW - COPD
KW - Particulate matter
KW - Welding fume
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U2 - 10.4209/aaqr.210272
DO - 10.4209/aaqr.210272
M3 - Article
AN - SCOPUS:85129343335
SN - 1680-8584
VL - 22
JO - Aerosol and Air Quality Research
JF - Aerosol and Air Quality Research
IS - 5
M1 - 210272
ER -