Abstract
Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.
Original language | English |
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Article number | 291 |
Journal | BMC Nephrology |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sept 7 2017 |
Keywords
- Cardiovascular
- Endothelin
- Renal failure
ASJC Scopus subject areas
- Nephrology
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Additional file 1: Table S1. of Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure
Zhang, Y.-F. (Creator), Cheng, S.-Y. (Creator), Kao, C.-C. (Contributor), Lu, H.-F. (Contributor), Hsu, Y.-W. (Creator), Wu, M.-S. (Creator), Chien, S.-C. (Creator), Wu, M.-Y. (Creator) & Chang, W.-C. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3874468_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3874468_d1.v1
Dataset
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Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure
Kao, C.-C. (Contributor), Cheng, S.-Y. (Creator), Wu, M.-Y. (Creator), Chien, S.-C. (Creator), Lu, H.-F. (Contributor), Hsu, Y.-W. (Creator), Zhang, Y.-F. (Creator), Wu, M.-S. (Creator) & Chang, W.-C. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3874468.v1, https://doi.org/10.6084%2Fm9.figshare.c.3874468.v1
Dataset