TY - JOUR
T1 - Associations between particulate sulfate and organic carbon exposures and heart rate variability in patients with or at risk for cardiovascular diseases
AU - Chuang, Kai Jen
AU - Chan, Chang Chuan
AU - Su, Ta Chen
AU - Lin, Lian Yu
AU - Lee, Chung Te
PY - 2007/6
Y1 - 2007/6
N2 - OBJECTIVE: It is still unknown whether specific components in fine particles are associated with heart rate variability (HRV) reduction. METHODS: We recruited 46 patients with or at risk for cardiovascular diseases to measure 24-hour HRV by ambulatory electrocardiographic monitoring. Fixed-site air-monitoring stations were used to represent participants' exposures to particles with aerodynamic diameters less than 10 μm (PM10) and 2.5 μm (PM2.5), and particulate components of sulfate, nitrate, organic carbon (OC) and elemental carbon, and gaseous pollutants. RESULTS: We found that HRV reduction was associated with sulfate, OC, and PM2.5 but not with the other five pollutants in single-pollutant models. Sulfate was found to remain in significant association with HRV reduction adjusting for OC and PM2.5 in three-pollutant models. CONCLUSIONS: Exposures to sulfate and OC in PM2.5 were associated with HRV reduction in patients with or at risk for cardiovascular diseases.
AB - OBJECTIVE: It is still unknown whether specific components in fine particles are associated with heart rate variability (HRV) reduction. METHODS: We recruited 46 patients with or at risk for cardiovascular diseases to measure 24-hour HRV by ambulatory electrocardiographic monitoring. Fixed-site air-monitoring stations were used to represent participants' exposures to particles with aerodynamic diameters less than 10 μm (PM10) and 2.5 μm (PM2.5), and particulate components of sulfate, nitrate, organic carbon (OC) and elemental carbon, and gaseous pollutants. RESULTS: We found that HRV reduction was associated with sulfate, OC, and PM2.5 but not with the other five pollutants in single-pollutant models. Sulfate was found to remain in significant association with HRV reduction adjusting for OC and PM2.5 in three-pollutant models. CONCLUSIONS: Exposures to sulfate and OC in PM2.5 were associated with HRV reduction in patients with or at risk for cardiovascular diseases.
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U2 - 10.1097/JOM.0b013e318058205b
DO - 10.1097/JOM.0b013e318058205b
M3 - Article
C2 - 17563603
AN - SCOPUS:34250366114
SN - 1076-2752
VL - 49
SP - 610
EP - 617
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 6
ER -
