Associations between MTHFR polymorphisms and the risk of potentially malignant oral disorders

T. Senghore, Y.-F. Li, F.-C. Sung, M.-H. Tsai, C.-H. Hua, C.-S. Liu, M.-F. Hung, C.-C. Yeh

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1 Citation (Scopus)


Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs). Materials and Methods: Genotypes of the MTHFR C677T and A1298C polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: The C677T T allele-carrying genotypes were significantly associated with a decreased risk of PMODs [odds ratio (OR)=0.62, 95% confidence interval (CI)=0.44-0.86]. Haplotype analysis also indicated that the 677T/1298A haplotype was associated with a decreased risk of PMODs (OR=0.56, 95%CI=0.40-0.80). No significant interaction was observed between MTHFR polymorphisms and lifestyle factors. Conclusion: Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples. © 2018 International Institute of Anticancer Research. All rights reserved.
Original languageEnglish
Pages (from-to)4021-4026
Number of pages6
JournalAnticancer Research
Issue number7
Publication statusPublished - 2018


  • Genetic polymorphism
  • Methylenetetrahydrofolate reductase
  • Potentially malignant oral disorders
  • Taiwan
  • 5,10 methylenetetrahydrofolate reductase (FADH2)
  • genomic DNA
  • methylenetetrahydrofolate reductase (NADPH2)
  • adult
  • alcohol consumption
  • allele
  • Article
  • carcinogenesis
  • cigarette smoking
  • comparative study
  • controlled study
  • genetic association
  • genotype
  • haplotype
  • human
  • lifestyle
  • major clinical study
  • male
  • molecular pathology
  • mouth carcinoma
  • potentially malignant oral disorder
  • priority journal
  • procedures
  • risk reduction
  • single nucleotide polymorphism
  • case control study
  • genetic predisposition
  • genetics
  • middle aged
  • mouth tumor
  • polymerase chain reaction
  • restriction fragment length polymorphism
  • Adult
  • Alleles
  • Case-Control Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Middle Aged
  • Mouth Neoplasms
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide


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