Associations among the CHADS 2 score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation

Tze Fan Chao; Chen Chuan Cheng; Wei Shiang Lin; Hsuan Ming Tsao; Yenn Jiang Lin; Shih Lin Chang; Li Wei Lo; Yu Feng Hu; Ta Chuan Tuan; Kazuyoshi Suenari; Cheng Hung Li; Shuen Hsin Liu; Beny Hartono; Tsu Juey Wu; Shih Ann Chen

doi:10.1016/j.hrthm.2011.03.016

Associations among the CHADS ₂ score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation

Tze Fan Chao, Chen Chuan Cheng, Wei Shiang Lin, Hsuan Ming Tsao, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Kazuyoshi Suenari, Cheng Hung Li, Shuen Hsin Liu, Beny Hartono, Tsu Juey Wu, Shih Ann Chen

Taipei Medical University Shuang Ho Hospital

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Background: The CHADS ₂ score (congestive heart failure, hypertension, age >75 years, diabetes, and previous stroke/transient ischemic attack) is used for the risk stratification of strokes in patients with atrial fibrillation (AF). Objective: This study aimed to investigate the associations between the CHADS ₂ score, atrial substrate, and outcome of catheter ablation in patients with paroxysmal AF. Methods: A total of 247 paroxysmal AF patients who received catheter ablation were enrolled. The patients were divided into 3 groups according to their CHADS ₂ score (group 1: score 0, group 2: score 1 to 2, and group 3: score 3 to 6). The bi-atrial substrate properties and outcome of catheter ablation were analyzed. Results: The CHADS ₂ scores in these 3 groups were 0 (group 1), 1.24 ± 0.48 (group 2), and 3.60 ± 0.83 (group 3), respectively. The left atrial voltage became lower (group 1 vs. 2 vs. 3 = 2.08 ± 0.73 mV vs. 1.80 ± 0.81 mV vs. 1.06 ± 0.69 mV) and the activation time longer (group 1 vs. 2 vs. 3 = 93.4 ± 17.7 ms vs. 101.9 ± 21.2 ms vs. 112.2 ± 21.7 ms), whereas the CHADS ₂ score increased. During a follow-up of 17.3 ± 7.0 months, 23.1% of the study population suffered from recurrences. The recurrence rates of these 3 groups were 13.0% (group 1), 27.6% (group 2), and 45.9% (group 3), respectively. The groups of different CHADS ₂ scores remained as the independent predictor of recurrence in the multivariate analysis. Conclusion: A high CHADS ₂ score was associated with different left atrial substrate properties and a poor outcome after catheter ablation of paroxysmal AF.

Original language	English
Pages (from-to)	1155-1159
Number of pages	5
Journal	Heart Rhythm
Volume	8
Issue number	8
DOIs	https://doi.org/10.1016/j.hrthm.2011.03.016
Publication status	Published - Aug 2011

Keywords

Atrial fibrillation
Catheter ablation
CHADS score
Recurrence
Substrate properties

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.hrthm.2011.03.016

Cite this

Chao, T. F., Cheng, C. C., Lin, W. S., Tsao, H. M., Lin, Y. J., Chang, S. L., Lo, L. W., Hu, Y. F., Tuan, T. C., Suenari, K., Li, C. H., Liu, S. H., Hartono, B., Wu, T. J., & Chen, S. A. (2011). Associations among the CHADS ₂ score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation. Heart Rhythm, 8(8), 1155-1159. https://doi.org/10.1016/j.hrthm.2011.03.016

Chao, TF, Cheng, CC, Lin, WS, Tsao, HM, Lin, YJ, Chang, SL, Lo, LW, Hu, YF, Tuan, TC, Suenari, K, Li, CH, Liu, SH, Hartono, B, Wu, TJ & Chen, SA 2011, 'Associations among the CHADS ₂ score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation', Heart Rhythm, vol. 8, no. 8, pp. 1155-1159. https://doi.org/10.1016/j.hrthm.2011.03.016

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title = "Associations among the CHADS 2 score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation",

abstract = "Background: The CHADS 2 score (congestive heart failure, hypertension, age >75 years, diabetes, and previous stroke/transient ischemic attack) is used for the risk stratification of strokes in patients with atrial fibrillation (AF). Objective: This study aimed to investigate the associations between the CHADS 2 score, atrial substrate, and outcome of catheter ablation in patients with paroxysmal AF. Methods: A total of 247 paroxysmal AF patients who received catheter ablation were enrolled. The patients were divided into 3 groups according to their CHADS 2 score (group 1: score 0, group 2: score 1 to 2, and group 3: score 3 to 6). The bi-atrial substrate properties and outcome of catheter ablation were analyzed. Results: The CHADS 2 scores in these 3 groups were 0 (group 1), 1.24 ± 0.48 (group 2), and 3.60 ± 0.83 (group 3), respectively. The left atrial voltage became lower (group 1 vs. 2 vs. 3 = 2.08 ± 0.73 mV vs. 1.80 ± 0.81 mV vs. 1.06 ± 0.69 mV) and the activation time longer (group 1 vs. 2 vs. 3 = 93.4 ± 17.7 ms vs. 101.9 ± 21.2 ms vs. 112.2 ± 21.7 ms), whereas the CHADS 2 score increased. During a follow-up of 17.3 ± 7.0 months, 23.1% of the study population suffered from recurrences. The recurrence rates of these 3 groups were 13.0% (group 1), 27.6% (group 2), and 45.9% (group 3), respectively. The groups of different CHADS 2 scores remained as the independent predictor of recurrence in the multivariate analysis. Conclusion: A high CHADS 2 score was associated with different left atrial substrate properties and a poor outcome after catheter ablation of paroxysmal AF.",

keywords = "Atrial fibrillation, Catheter ablation, CHADS score, Recurrence, Substrate properties",

author = "Chao, {Tze Fan} and Cheng, {Chen Chuan} and Lin, {Wei Shiang} and Tsao, {Hsuan Ming} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Tuan, {Ta Chuan} and Kazuyoshi Suenari and Li, {Cheng Hung} and Liu, {Shuen Hsin} and Beny Hartono and Wu, {Tsu Juey} and Chen, {Shih Ann}",

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doi = "10.1016/j.hrthm.2011.03.016",

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T1 - Associations among the CHADS 2 score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation

AU - Chao, Tze Fan

AU - Cheng, Chen Chuan

AU - Lin, Wei Shiang

AU - Tsao, Hsuan Ming

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Tuan, Ta Chuan

AU - Suenari, Kazuyoshi

AU - Li, Cheng Hung

AU - Liu, Shuen Hsin

AU - Hartono, Beny

AU - Wu, Tsu Juey

AU - Chen, Shih Ann

PY - 2011/8

Y1 - 2011/8

N2 - Background: The CHADS 2 score (congestive heart failure, hypertension, age >75 years, diabetes, and previous stroke/transient ischemic attack) is used for the risk stratification of strokes in patients with atrial fibrillation (AF). Objective: This study aimed to investigate the associations between the CHADS 2 score, atrial substrate, and outcome of catheter ablation in patients with paroxysmal AF. Methods: A total of 247 paroxysmal AF patients who received catheter ablation were enrolled. The patients were divided into 3 groups according to their CHADS 2 score (group 1: score 0, group 2: score 1 to 2, and group 3: score 3 to 6). The bi-atrial substrate properties and outcome of catheter ablation were analyzed. Results: The CHADS 2 scores in these 3 groups were 0 (group 1), 1.24 ± 0.48 (group 2), and 3.60 ± 0.83 (group 3), respectively. The left atrial voltage became lower (group 1 vs. 2 vs. 3 = 2.08 ± 0.73 mV vs. 1.80 ± 0.81 mV vs. 1.06 ± 0.69 mV) and the activation time longer (group 1 vs. 2 vs. 3 = 93.4 ± 17.7 ms vs. 101.9 ± 21.2 ms vs. 112.2 ± 21.7 ms), whereas the CHADS 2 score increased. During a follow-up of 17.3 ± 7.0 months, 23.1% of the study population suffered from recurrences. The recurrence rates of these 3 groups were 13.0% (group 1), 27.6% (group 2), and 45.9% (group 3), respectively. The groups of different CHADS 2 scores remained as the independent predictor of recurrence in the multivariate analysis. Conclusion: A high CHADS 2 score was associated with different left atrial substrate properties and a poor outcome after catheter ablation of paroxysmal AF.

AB - Background: The CHADS 2 score (congestive heart failure, hypertension, age >75 years, diabetes, and previous stroke/transient ischemic attack) is used for the risk stratification of strokes in patients with atrial fibrillation (AF). Objective: This study aimed to investigate the associations between the CHADS 2 score, atrial substrate, and outcome of catheter ablation in patients with paroxysmal AF. Methods: A total of 247 paroxysmal AF patients who received catheter ablation were enrolled. The patients were divided into 3 groups according to their CHADS 2 score (group 1: score 0, group 2: score 1 to 2, and group 3: score 3 to 6). The bi-atrial substrate properties and outcome of catheter ablation were analyzed. Results: The CHADS 2 scores in these 3 groups were 0 (group 1), 1.24 ± 0.48 (group 2), and 3.60 ± 0.83 (group 3), respectively. The left atrial voltage became lower (group 1 vs. 2 vs. 3 = 2.08 ± 0.73 mV vs. 1.80 ± 0.81 mV vs. 1.06 ± 0.69 mV) and the activation time longer (group 1 vs. 2 vs. 3 = 93.4 ± 17.7 ms vs. 101.9 ± 21.2 ms vs. 112.2 ± 21.7 ms), whereas the CHADS 2 score increased. During a follow-up of 17.3 ± 7.0 months, 23.1% of the study population suffered from recurrences. The recurrence rates of these 3 groups were 13.0% (group 1), 27.6% (group 2), and 45.9% (group 3), respectively. The groups of different CHADS 2 scores remained as the independent predictor of recurrence in the multivariate analysis. Conclusion: A high CHADS 2 score was associated with different left atrial substrate properties and a poor outcome after catheter ablation of paroxysmal AF.

KW - Atrial fibrillation

KW - Catheter ablation

KW - CHADS score

KW - Recurrence

KW - Substrate properties

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