TY - JOUR
T1 - Association of white blood cell count and peripheral arterial disease in patients with and without traditional risk factors
AU - Chen, Jien Jiun
AU - Lin, Lian Yu
AU - Lee, Hsiu Hao
AU - Lai, Lin Ping
AU - Lin, Jiunn Lee
AU - Huang, Juey Jen
AU - Tseng, Chuen Den
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Peripheral arterial disease (PAD) is an inflammatory process. The association between white blood cell (WBC) count and PAD in those with and without traditional risk factors is not clear. We examined data from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. A total of 5260 participants were included. The result showed that the prevalence of PAD rose from 2.8% ± 0.5% in the lowest quartile of plasma WBC count to 8.0% ± 1.2% in the highest quartile. In subgroup analysis, the graded association between WBC count and PAD was significant in patients without hypertension, diabetes, smoking, chronic kidney disease (CKD), and in patients with or without hypercholesterolemia but not significant in patients with hypertension, smoking, diabetes, or CKD. In those without hypertension, diabetes, smoking, or CKD, the cutoff value for WBC count was 6.75 Ã-109/L. We concluded that the positive association between WBC count and PAD can be demonstrated in this national survey.
AB - Peripheral arterial disease (PAD) is an inflammatory process. The association between white blood cell (WBC) count and PAD in those with and without traditional risk factors is not clear. We examined data from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. A total of 5260 participants were included. The result showed that the prevalence of PAD rose from 2.8% ± 0.5% in the lowest quartile of plasma WBC count to 8.0% ± 1.2% in the highest quartile. In subgroup analysis, the graded association between WBC count and PAD was significant in patients without hypertension, diabetes, smoking, chronic kidney disease (CKD), and in patients with or without hypercholesterolemia but not significant in patients with hypertension, smoking, diabetes, or CKD. In those without hypertension, diabetes, smoking, or CKD, the cutoff value for WBC count was 6.75 Ã-109/L. We concluded that the positive association between WBC count and PAD can be demonstrated in this national survey.
KW - Chronic kidney disease
KW - Diabetes
KW - Hypercholesterolemia
KW - Inflammation
KW - Peripheral artery disease
KW - White blood cell count
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U2 - 10.1177/0003319709344575
DO - 10.1177/0003319709344575
M3 - Article
C2 - 19689993
AN - SCOPUS:77952738481
SN - 0003-3197
VL - 61
SP - 382
EP - 387
JO - Angiology
JF - Angiology
IS - 4
ER -
