Association of traffic air pollution with severity of obstructive sleep apnea in urban areas of Northern Taiwan: A cross-sectional study

Background: Although recent studies have indicated an association between obstructive sleep apnea (OSA) and air pollution, they have reported inconsistent results. Moreover, few studies investigated the effects of short-term air pollution exposure. Objective: To estimate the health effects of short- and long-term exposure to traffic air pollution on mild OSA in Taipei. Methods: We collected participants' data from Taipei Sleep Center and air pollution data from Taiwan Environmental Protection Administration. A spatiotemporal model was used to estimate the individual exposure level. Generalized linear models were used to assess the percent change of overall apnea-hypopnea index (AHI), AHI in rapid eye movement period (AHI-REM), AHI in non-REM (AHI-NREM), and oxygen desaturation index (ODI) associated with an interquartile (IQR) increase in personal pollution exposure. A generalized logistic model was used to estimate the ORs of different severities of OSA compared with the reference group. Results: In the patients with AHI of <15, both short- and long-term exposure to NO₂ were significantly associated with AHI and ODI increases: an IQR increase in 2-year mean NO₂ increased 7.3% of AHI and 8.4% of ODI; these values were the highest among all exposure windows. The effects of NO₂ on AHI increase were stronger in the men and younger patients. Moreover, the association between AHI and NO₂ in the patients with AHI of <15 was mediated by the REM stage. NO₂ exposure was associated with an increased risk of mild OSA that reached up to 24.8% per IQR increase in NO₂ averaged over 2 years. PM_2.5 exerted no effects on AHI, but an IQR increase in 1-year and 2-year mean PM_2.5 was associated with 6.8% and 8.8% increases in ODI, respectively. Conclusions: Both short- and long-term exposure to traffic air pollution were associated with the risk of mild OSA, which was modified by REM stage.