Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 205-210 |
| Number of pages | 6 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 |
| Externally published | Yes |
Keywords
- ADRA1A gene
- ADRA2A gene
- ADRB3 gene
- Metabolic syndrome
- Schizophrenia
- high density lipoprotein cholesterol
- neuroleptic agent
- triacylglycerol
- 5HT2A gene
- adult
- article
- blood pressure measurement
- body mass
- cardiovascular risk
- cholesterol blood level
- controlled study
- disease severity
- female
- gene
- gene frequency
- gene function
- genetic analysis
- genetic association
- genotype
- glucose blood level
- heterozygosity
- homozygosity
- human
- major clinical study
- male
- metabolic syndrome X
- patient monitoring
- prevalence
- schizophrenia
- single nucleotide polymorphism
- triacylglycerol blood level
- waist circumference
- Adult
- Arginine
- Cysteine
- Female
- Gene Frequency
- Genetic Association Studies
- Humans
- Male
- Metabolic Syndrome X
- Middle Aged
- Polymorphism, Single Nucleotide
- Receptors, Adrenergic, alpha-1
- Risk Factors
- Severity of Illness Index
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Association of the ADRA1A gene and the severity of metabolic abnormalities in patients with schizophrenia. / Cheng, Chin; Chiu, Hsien-Jane; Loh, El-Wui et al.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 36, No. 1, 2012, p. 205-210.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Association of the ADRA1A gene and the severity of metabolic abnormalities in patients with schizophrenia
AU - Cheng, Chin
AU - Chiu, Hsien-Jane
AU - Loh, El-Wui
AU - Chan, Chin-Hong
AU - Hwu, Tzong-Ming
AU - Liu, Yun-Ru
AU - Lan, Tsuo-Hung
N1 - 被引用次數：7 Export Date: 29 March 2016 CODEN: PNPPD 通訊地址: Cheng, C.; Department of Psychiatry, Faculty of Medicine, National Yang-Ming University, No. 155, Sec.2, Linong Street, Taipei, 112, Taiwan; 電子郵件： ccchinnn@gmail.com 化學物質/CAS: ADRA1A protein, human; Arginine, 74-79-3; Cysteine, 52-90-4; Receptors, Adrenergic, alpha-1 參考文獻: Alberti, K.G., Zimmet, P., Shaw, J., The metabolic syndrome-a new worldwide definition (2005) Lancet, 366, pp. 1059-1062; Arii, K., Suehiro, T., Yamamoto, M., Ito, H., Ikeda, Y., Nakauchi, Y., Trp64Arg mutation of beta 3-adrenergic receptor and insulin sensitivity in subjects with glucose intolerance (1997) Internal Medicine, 36, pp. 603-606; Basile, V.S., Masellis, M., McIntyre, R.S., Meltzer, H.Y., Lieberman, J.A., Kennedy, J.L., Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle (2001) The Journal of Clinical Psychiatry, 62 (SUPPL. 23), pp. 45-66; Bayturan, O., Tuzcu, E.M., Lavoie, A., Hu, T., Wolski, K., Schoenhagen, P., The metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis (2010) Archives of Internal Medicine, 170, pp. 478-484; 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PY - 2012
Y1 - 2012
N2 - Patients with schizophrenia have a higher risk of developing metabolic abnormalities and their associated diseases. Some studies found that the accumulative number of metabolic syndrome components was associated with the severity of metabolic abnormalities. The purpose of this study was to examine the roles of the ADRA1A, ADRA2A, ADRB3, and 5HT2A genes in the risk of having more severe metabolic abnormalities among patients with schizophrenia. We studied a sample of 232 chronic inpatients with schizophrenia (120 males and 112 females) to explore the associations between the four candidate genes and the severity of metabolic syndrome by accumulative number of the components. Four single nucleotide polymorphisms in the candidate genes were genotyped, including the Arg347Cys in ADRA1A, the C1291G in ADRA2A, the Try64Arg in ADRB3, and the T102C in 5HT2A. An association between the accumulative number of metabolic syndrome components and the ADRA1A gene was found after adjusting age, sex, and other related variables (p-value = 0.036). Presence of the Arg347 allele in the ADRA1A gene is a risk factor for having more severe metabolic abnormalities. These findings suggest a medical attention of closely monitoring metabolic risks for schizophrenia patients with high-risk genotypes. © 2011 Elsevier Inc.
AB - Patients with schizophrenia have a higher risk of developing metabolic abnormalities and their associated diseases. Some studies found that the accumulative number of metabolic syndrome components was associated with the severity of metabolic abnormalities. The purpose of this study was to examine the roles of the ADRA1A, ADRA2A, ADRB3, and 5HT2A genes in the risk of having more severe metabolic abnormalities among patients with schizophrenia. We studied a sample of 232 chronic inpatients with schizophrenia (120 males and 112 females) to explore the associations between the four candidate genes and the severity of metabolic syndrome by accumulative number of the components. Four single nucleotide polymorphisms in the candidate genes were genotyped, including the Arg347Cys in ADRA1A, the C1291G in ADRA2A, the Try64Arg in ADRB3, and the T102C in 5HT2A. An association between the accumulative number of metabolic syndrome components and the ADRA1A gene was found after adjusting age, sex, and other related variables (p-value = 0.036). Presence of the Arg347 allele in the ADRA1A gene is a risk factor for having more severe metabolic abnormalities. These findings suggest a medical attention of closely monitoring metabolic risks for schizophrenia patients with high-risk genotypes. © 2011 Elsevier Inc.
KW - ADRA1A gene
KW - ADRA2A gene
KW - ADRB3 gene
KW - Metabolic syndrome
KW - Schizophrenia
KW - high density lipoprotein cholesterol
KW - neuroleptic agent
KW - triacylglycerol
KW - 5HT2A gene
KW - adult
KW - article
KW - blood pressure measurement
KW - body mass
KW - cardiovascular risk
KW - cholesterol blood level
KW - controlled study
KW - disease severity
KW - female
KW - gene
KW - gene frequency
KW - gene function
KW - genetic analysis
KW - genetic association
KW - genotype
KW - glucose blood level
KW - heterozygosity
KW - homozygosity
KW - human
KW - major clinical study
KW - male
KW - metabolic syndrome X
KW - patient monitoring
KW - prevalence
KW - schizophrenia
KW - single nucleotide polymorphism
KW - triacylglycerol blood level
KW - waist circumference
KW - Adult
KW - Arginine
KW - Cysteine
KW - Female
KW - Gene Frequency
KW - Genetic Association Studies
KW - Humans
KW - Male
KW - Metabolic Syndrome X
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Receptors, Adrenergic, alpha-1
KW - Risk Factors
KW - Severity of Illness Index
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-82555176502&origin=inward&txGid=c28b303ce9413296cdd534db2d8cd951
UR - https://www.scopus.com/results/citedbyresults.uri?sort=plf-f&cite=2-s2.0-82555176502&src=s&imp=t&sid=7e344e2378aa9bba5197d4b41016f29b&sot=cite&sdt=a&sl=0&origin=recordpage&editSaveSearch=&txGid=98a2c4300bfc59b3b3dc6d3bf14f5fd7
U2 - 10.1016/j.pnpbp.2011.10.011
DO - 10.1016/j.pnpbp.2011.10.011
M3 - Article
SN - 0278-5846
VL - 36
SP - 205
EP - 210
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 1
ER -