Association of serum bilirubin levels with albuminuria in patients with essential hypertension

Shao Sung Huang, Po Hsun Huang, Kuang Hsing Chiang, Jaw Wen Chen, Shing Jong Lin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objectives: This study was undertaken to evaluate the relationship between serum bilirubin concentrations and the degree of urinary albumin excretion in hypertensive patients. Design and methods: A total of 120 hypertensive subjects were enrolled, in which 80 (67%) with normoalbuminuria (albumin excretion rate [AER] of < 20 μg/min), 30 (25%) with microalbuminuria (AER of 20-200 μg/min) and 10 (8%) with macroalbuminuria (AER > 200 μg/min). Logarithmic (log) transformation of urinary albumin excretion was carried out before performing correlation and regression analysis. Results: Patients with micro- or macroalbuminuria had significantly lower serum bilirubin concentrations (P= 0.004). By multivariate regression analysis, serum bilirubin concentration was an independent determinant of albuminuria and had an inverse correlation with log (urinary albumin excretion) in hypertensive patients (β= -0.189, P= 0.023). Conclusions: These findings may partly explain the pathogenetic processes that link microalbuminuria and enhanced cardiovascular risk in hypertensive patients.

Original languageEnglish
Pages (from-to)859-863
Number of pages5
JournalClinical Biochemistry
Volume44
Issue number10-11
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Keywords

  • Albuminuria
  • Bilirubin
  • Hypertension

ASJC Scopus subject areas

  • Clinical Biochemistry

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