TY - JOUR
T1 - Association of rosacea with depression and anxiety
T2 - A systematic review and meta-analysis
AU - Chang, Hua Ching
AU - Huang, Yu Chen
AU - Lien, Yueh Ju
AU - Chang, Yin Shuo
N1 - Funding Information:
None.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2022/2/15
Y1 - 2022/2/15
N2 - Background: Rosacea is associated with several comorbidities, but its relationship with psychiatric disorders remains controversial. We aimed to investigate the association of rosacea with depression and anxiety. Methods: A systematic review was performed of relevant observational studies in the PubMed, Web of Science, Embase, and Wanfang databases from inception to June 8, 2021. The inclusion criteria for eligible studies were observational studies comparing the incidence or prevalence of depression or anxiety between patients with rosacea and individuals without rosacea. We conducted meta-analyses with a random-effects model. The main outcome was pooled analysis of prevalence or incidence of depression and anxiety in patients with rosacea. Results: We included nine studies with 101,114,209 patients with rosacea. A pooled analysis from cross-sectional and case–control studies revealed that patients with rosacea were significantly more likely to have depression (crude odds ratio [OR], 2.855; 95% confidence interval [CI], 1.258–6.481) and anxiety (crude OR, 2.373; 95% CI, 1.448–3.888) than matched controls; however, adjusted ORs showed no significant association. Furthermore, the meta-analysis from cohort studies indicated that patients with rosacea have significantly higher risks of developing depression (adjusted incidence rate ratio [IRR], 2.443; 95% CI, 1.603–3.723) and anxiety (adjusted IRR, 2.181; 95% CI, 1.660–2.864). Limitations: Data for a subgroup analysis based on different demographic factors were insufficient. Conclusions: Current findings provide more evidence that rosacea is significantly associated with depression and anxiety, and rosacea may predispose patients to develop depression and anxiety. Clinicians should be aware of the psychological aspects of rosacea.
AB - Background: Rosacea is associated with several comorbidities, but its relationship with psychiatric disorders remains controversial. We aimed to investigate the association of rosacea with depression and anxiety. Methods: A systematic review was performed of relevant observational studies in the PubMed, Web of Science, Embase, and Wanfang databases from inception to June 8, 2021. The inclusion criteria for eligible studies were observational studies comparing the incidence or prevalence of depression or anxiety between patients with rosacea and individuals without rosacea. We conducted meta-analyses with a random-effects model. The main outcome was pooled analysis of prevalence or incidence of depression and anxiety in patients with rosacea. Results: We included nine studies with 101,114,209 patients with rosacea. A pooled analysis from cross-sectional and case–control studies revealed that patients with rosacea were significantly more likely to have depression (crude odds ratio [OR], 2.855; 95% confidence interval [CI], 1.258–6.481) and anxiety (crude OR, 2.373; 95% CI, 1.448–3.888) than matched controls; however, adjusted ORs showed no significant association. Furthermore, the meta-analysis from cohort studies indicated that patients with rosacea have significantly higher risks of developing depression (adjusted incidence rate ratio [IRR], 2.443; 95% CI, 1.603–3.723) and anxiety (adjusted IRR, 2.181; 95% CI, 1.660–2.864). Limitations: Data for a subgroup analysis based on different demographic factors were insufficient. Conclusions: Current findings provide more evidence that rosacea is significantly associated with depression and anxiety, and rosacea may predispose patients to develop depression and anxiety. Clinicians should be aware of the psychological aspects of rosacea.
KW - Anxiety
KW - Depression
KW - Meta-analysis
KW - Rosacea
KW - Systematic review
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U2 - 10.1016/j.jad.2021.12.008
DO - 10.1016/j.jad.2021.12.008
M3 - Review article
C2 - 34879261
AN - SCOPUS:85120961956
SN - 0165-0327
VL - 299
SP - 239
EP - 245
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -