Association of Nasopharynx Cancer with Human Papillomavirus Infections

Shih Han Hung, Tzong Hann Yang, Yen Fu Cheng, Chin Shyan Chen, Herng Ching Lin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient’s residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%, p < 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763–2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421–2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma.

Original languageEnglish
Article number4082
Issue number16
Publication statusPublished - Aug 2023


  • epidemiology
  • human papillomavirus
  • human papillomavirus infection
  • nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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