Association of HPV infections with second primary tumors in early-staged oral cavity cancer

S. F. Huang, H. F. Li, C. T. Liao, H. M. Wang, I. H. Chen, J. T.C. Chang, Y. J. Chen, A. J. Cheng

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Objective: The infection of human papilloma virus (HPV) has been reported in head and neck cancer; however, the clinical significance of HPV infection on the pathogenesis of oral cavity squamous cell carcinoma (OSCC) is still uncertain. Materials and Methods: The study recruited 103 patients with pathological early-stage OSCC between March 1997 and December 2003 from Chang Gung Memorial Hospital, Taiwan. Tumor specimens were HPV-genotyped by the EasychipVR HPV Blot method. Clinical association study was performed by using chi-square, Kaplan-Meier, and logrank tests. Results: Thirty-one patients (30.1%) were positive for HPV infection. The most frequent HPV types were types 16 (16 patients, 51.6%) and 18 (seven patients, 22.6%). HPV infection was not associated with tumor aggressiveness (pathological tumor stage or differentiation status), risk exposure (alcohol, cigarette, or areca quid chewing habit), or the treatment outcome (disease-free survival or overall survival). However, infection with HPV-18 was associated with the occurrence of a second primary cancers (P=0.033), indicating the infection of HPV in OSCC enhances the susceptibility of developing secondary malignancy. Conclusions: There are 30% of the patients with OSCC infected with HPV, with most high-risk types. HPV-18 infection may enhance the susceptibility of second primary tumors. Large scale of validation study will be needed to confirm this result.

Original languageEnglish
Pages (from-to)809-815
Number of pages7
JournalOral Diseases
Issue number8
Publication statusPublished - Nov 2012
Externally publishedYes


  • Clinical association
  • Human papilloma virus
  • Oral cavity cancer
  • Risk exposure
  • Secondary malignancy

ASJC Scopus subject areas

  • Otorhinolaryngology
  • General Dentistry


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