Objective: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Methods: Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (

Original languageEnglish
Pages (from-to)704-708
Number of pages5
Issue number2
Publication statusPublished - Dec 2011


  • Blood pressure
  • Cardiovascular mortality
  • Genetic polymorphism
  • Heme oxygenase-1
  • Population study
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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