Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals

Meei Maan Wu; Hung Yi Chiou; Chi Ling Chen; Ling I. Hsu; Li Ming Lien; Chih Hao Wang; Yi Chen Hsieh; Yuan Hung Wang; Yu Mei Hsueh; Te Chang Lee; Wen Fang Cheng; Chien Jen Chen

doi:10.1016/j.atherosclerosis.2011.08.047

Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals

Meei Maan Wu, Hung Yi Chiou, Chi Ling Chen, Ling I. Hsu, Li Ming Lien, Chih Hao Wang, Yi Chen Hsieh, Yuan Hung Wang, Yu Mei Hsueh, Te Chang Lee, Wen Fang Cheng, Chien Jen Chen

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Objective: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Methods: Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (

Original language	English
Pages (from-to)	704-708
Number of pages	5
Journal	Atherosclerosis
Volume	219
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2011.08.047
Publication status	Published - Dec 2011

Keywords

Blood pressure
Cardiovascular mortality
Genetic polymorphism
Heme oxygenase-1
Population study
Risk factors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2011.08.047

Cite this

Wu, M. M., Chiou, H. Y., Chen, C. L., Hsu, L. I., Lien, L. M., Wang, C. H., Hsieh, Y. C., Wang, Y. H., Hsueh, Y. M., Lee, T. C., Cheng, W. F., & Chen, C. J. (2011). Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals. Atherosclerosis, 219(2), 704-708. https://doi.org/10.1016/j.atherosclerosis.2011.08.047

Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals. / Wu, Meei Maan ; Chiou, Hung Yi; Chen, Chi Ling et al.
In: Atherosclerosis, Vol. 219, No. 2, 12.2011, p. 704-708.

Research output: Contribution to journal › Article › peer-review

Wu, MM , Chiou, HY, Chen, CL, Hsu, LI, Lien, LM, Wang, CH, Hsieh, YC , Wang, YH, Hsueh, YM, Lee, TC, Cheng, WF & Chen, CJ 2011, 'Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals', Atherosclerosis, vol. 219, no. 2, pp. 704-708. https://doi.org/10.1016/j.atherosclerosis.2011.08.047

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title = "Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals",

abstract = "Objective: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Methods: Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (",

keywords = "Blood pressure, Cardiovascular mortality, Genetic polymorphism, Heme oxygenase-1, Population study, Risk factors",

author = "Wu, {Meei Maan} and Chiou, {Hung Yi} and Chen, {Chi Ling} and Hsu, {Ling I.} and Lien, {Li Ming} and Wang, {Chih Hao} and Hsieh, {Yi Chen} and Wang, {Yuan Hung} and Hsueh, {Yu Mei} and Lee, {Te Chang} and Cheng, {Wen Fang} and Chen, {Chien Jen}",

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doi = "10.1016/j.atherosclerosis.2011.08.047",

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T2 - An observation based on arsenic-exposed individuals

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AU - Chiou, Hung Yi

AU - Chen, Chi Ling

AU - Hsu, Ling I.

AU - Lien, Li Ming

AU - Wang, Chih Hao

AU - Hsieh, Yi Chen

AU - Wang, Yuan Hung

AU - Hsueh, Yu Mei

AU - Lee, Te Chang

AU - Cheng, Wen Fang

AU - Chen, Chien Jen

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AB - Objective: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Methods: Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (

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KW - Cardiovascular mortality

KW - Genetic polymorphism

KW - Heme oxygenase-1

KW - Population study

KW - Risk factors

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Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals

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