TY - JOUR
T1 - Association of brachial-ankle pulse wave velocity with cardiovascular risk factors in systemic lupus erythematosus
AU - Tso, Tim K.
AU - Huang, W. N.
AU - Huang, H. Y.
AU - Chang, C. K.
PY - 2005/12/12
Y1 - 2005/12/12
N2 - Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis. Increasing arterial stiffness is closely associated with atherosclerotic cardiovascular diseases, and pulse wave velocity (PWV) is considered to be an indicator of arterial stiffness. The objective of this study was to identify the relationship between brachial-ankle pulse wave velocity (baPWV) and cardiovascular risk factors in patients with SLE. Age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBS), plasma lipid profile, plasma homocysteine, thiobarbituric acid reactive substances (TBARS), baPWV, ankle-brachial index (ABI), and SLE-related factors were determined in a total of 83 SLE patients (12 males and 71 females). All SLE patients were further classified into two subgroups according to baPWV value (baPWV < 1400 cm/s, n = 37 versus baPWV > 1400 cm/s, n = 46). The mean baPWV value of studied SLE patients was 1520 ± 381 cm/s. Age, BMI, SBP, DBP, FBS, TBARS and homocysteine levels were significantly higher in SLE patients with baPWV value > 1400 cm/s than in SLE patients with baPWV value < 1400 cm/s. In addition, baPWV correlated significantly with age, SBP, DBP, FBS and homocysteine. Moreover, stepwise multiple regression analysis showed that age and SBP were independently associated with baPWV. The results of this study indicate a possible link between vascular stiffness measured by baPWV and cardiovascular risk factors in patients with SLE.
AB - Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis. Increasing arterial stiffness is closely associated with atherosclerotic cardiovascular diseases, and pulse wave velocity (PWV) is considered to be an indicator of arterial stiffness. The objective of this study was to identify the relationship between brachial-ankle pulse wave velocity (baPWV) and cardiovascular risk factors in patients with SLE. Age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBS), plasma lipid profile, plasma homocysteine, thiobarbituric acid reactive substances (TBARS), baPWV, ankle-brachial index (ABI), and SLE-related factors were determined in a total of 83 SLE patients (12 males and 71 females). All SLE patients were further classified into two subgroups according to baPWV value (baPWV < 1400 cm/s, n = 37 versus baPWV > 1400 cm/s, n = 46). The mean baPWV value of studied SLE patients was 1520 ± 381 cm/s. Age, BMI, SBP, DBP, FBS, TBARS and homocysteine levels were significantly higher in SLE patients with baPWV value > 1400 cm/s than in SLE patients with baPWV value < 1400 cm/s. In addition, baPWV correlated significantly with age, SBP, DBP, FBS and homocysteine. Moreover, stepwise multiple regression analysis showed that age and SBP were independently associated with baPWV. The results of this study indicate a possible link between vascular stiffness measured by baPWV and cardiovascular risk factors in patients with SLE.
KW - Arterial stiffness
KW - Atherosclerosis
KW - Brachial-ankle pulse wave velocity
KW - Homocysteine
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=28444483563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444483563&partnerID=8YFLogxK
U2 - 10.1191/0961203305lu2234oa
DO - 10.1191/0961203305lu2234oa
M3 - Article
C2 - 16335579
AN - SCOPUS:28444483563
SN - 0961-2033
VL - 14
SP - 878
EP - 883
JO - Lupus
JF - Lupus
IS - 11
ER -
