TY - JOUR
T1 - Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery Disease
AU - Huang, Chin Chou
AU - Chang, Meng Ting
AU - Leu, Hsin Bang
AU - Yin, Wei Hsian
AU - Tseng, Wei Kung
AU - Wu, Yen Wen
AU - Lin, Tsung Hsien
AU - Yeh, Hung I.
AU - Chang, Kuan Cheng
AU - Wang, Ji Hung
AU - Wu, Chau Chung
AU - Shyur, Lie Fen
AU - Chen, Jaw Wen
N1 - Funding Information:
The authors thank the Metabolomics Core Facility of the Agricultural Biotechnology Research Center, Academia Sinica, Taiwan for its services, and Ms. Miranda Loney, Agricultural Biotechnology Research Center English Editor’s Office, Academia Sinica, Taiwan, for English editorial assistance. The authors also thank the technical services provided by the Health and Welfare Data Science Center, Taiwan. This work has been supported by research grants VTA107-V1-6-2 and VTA107-V1-6-3 from Taipei Veterans General Hospital, Taipei, Taiwan, VTA107-V1-6-1 and BM10501010039 from Academia Sinica, Taipei, Taiwan,=., and a research grant MOST 107-2314-B-075-061 from the Ministry of Science and Technology, Taiwan. The funders had no role in study design, data collection and analysis, preparation of the manuscript, or decision to publish.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Polyunsaturated fatty acids (PUFAs) have been suggested for cardiovascular health. This study was conducted to investigate the prognostic impacts of the PUFA metabolites, oxylipins, on clinical outcomes in coronary artery disease (CAD). A total of 2,239 patients with stable CAD were prospectively enrolled and followed up regularly. Among them, twenty-five consecutive patients with new onset of acute myocardial infarction (AMI) within 2-year follow-up were studied. Another 50 gender- and age-matched patients without clinical cardiovascular events for more than 2 years were studied for control. Baseline levels of specific arachidonic acid metabolites were significantly higher in patients with subsequent AMI than in the controls. In Kaplan-Meier analysis, the incidence of future AMI was more frequently seen in patients with higher baseline levels of 8-hydroxyeicosatetraenoic acid (HETE), 9-HETE, 11-HETE, 12-HETE, 15-HETE, 19-HETE, 20-HETE, 5,6-epoxyeicosatrienoic acid (EET), 8,9-EET, 11,12-EET, or 14-15-EET when compared to their counterparts (all the P < 0.01). Further, serum levels of these specific HETEs, except for 11,12-EET, were positively correlated to the levels of some inflammatory and cardiac biomarker such as tumor necrosis factor-α and N-terminal pro B-type natriuretic peptide. Accordingly, serum specific oxylipins levels are increased and associated with the consequent onset of AMI, suggesting their potential role for secondary prevention in clinically stable CAD.
AB - Polyunsaturated fatty acids (PUFAs) have been suggested for cardiovascular health. This study was conducted to investigate the prognostic impacts of the PUFA metabolites, oxylipins, on clinical outcomes in coronary artery disease (CAD). A total of 2,239 patients with stable CAD were prospectively enrolled and followed up regularly. Among them, twenty-five consecutive patients with new onset of acute myocardial infarction (AMI) within 2-year follow-up were studied. Another 50 gender- and age-matched patients without clinical cardiovascular events for more than 2 years were studied for control. Baseline levels of specific arachidonic acid metabolites were significantly higher in patients with subsequent AMI than in the controls. In Kaplan-Meier analysis, the incidence of future AMI was more frequently seen in patients with higher baseline levels of 8-hydroxyeicosatetraenoic acid (HETE), 9-HETE, 11-HETE, 12-HETE, 15-HETE, 19-HETE, 20-HETE, 5,6-epoxyeicosatrienoic acid (EET), 8,9-EET, 11,12-EET, or 14-15-EET when compared to their counterparts (all the P < 0.01). Further, serum levels of these specific HETEs, except for 11,12-EET, were positively correlated to the levels of some inflammatory and cardiac biomarker such as tumor necrosis factor-α and N-terminal pro B-type natriuretic peptide. Accordingly, serum specific oxylipins levels are increased and associated with the consequent onset of AMI, suggesting their potential role for secondary prevention in clinically stable CAD.
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U2 - 10.1038/s41598-020-65014-z
DO - 10.1038/s41598-020-65014-z
M3 - Article
C2 - 32415198
AN - SCOPUS:85084751317
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 8105
ER -