Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu; Shing Ming Sung; Hsing Cheng Liu; Jan Gowth Chang

doi:10.1016/S0022-510X(98)00052-5

Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Jan Gowth Chang

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

Original language	English
Pages (from-to)	158-161
Number of pages	4
Journal	Journal of the Neurological Sciences
Volume	157
Issue number	2
DOIs	https://doi.org/10.1016/S0022-510X(98)00052-5
Publication status	Published - May 7 1998
Externally published	Yes

Keywords

Alzheimer's disease
Apolipoprotein E
Chinese
Dementia
Genetics
Presenilin- 1

ASJC Scopus subject areas

Ageing
Clinical Neurology
Surgery
Neuroscience(all)
Developmental Neuroscience
Neurology

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10.1016/S0022-510X(98)00052-5

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abstract = "We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P",

keywords = "Alzheimer's disease, Apolipoprotein E, Chinese, Dementia, Genetics, Presenilin- 1",

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AU - Hu, Chaur Jong

AU - Sung, Shing Ming

AU - Liu, Hsing Cheng

AU - Chang, Jan Gowth

PY - 1998/5/7

Y1 - 1998/5/7

N2 - We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

AB - We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Chinese

KW - Dementia

KW - Genetics

KW - Presenilin- 1

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JF - Journal of the Neurological Sciences

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Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Abstract

Keywords

ASJC Scopus subject areas

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