Abstract
We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P<0.0001). The odds ratio for AD in individuals with either one or two ε4 alleles was 5.22 (95% confidence interval: 2.32- 11.70). The polymorphism within the region composing intron 3' to exon 8 of the PS-1 gene showed a similar distribution between AD patients and controls. This is the first study on the intronic polymorphism of the PS-1 gene in Chinese. Our results support an association between apoE ε4 and AD in Chinese, but not between the intronic polymorphism of the PS-1 gene and AD. However, the allele frequency of apo-E ε4 among Chinese is lower than that among Caucasians. The interaction between apo-E and PS-1 genotypes is still unclear.
Original language | English |
---|---|
Pages (from-to) | 158-161 |
Number of pages | 4 |
Journal | Journal of the Neurological Sciences |
Volume | 157 |
Issue number | 2 |
DOIs | |
Publication status | Published - May 7 1998 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Apolipoprotein E
- Chinese
- Dementia
- Genetics
- Presenilin- 1
ASJC Scopus subject areas
- Clinical Neurology
- Neurology