Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Jan Gowth Chang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P<0.0001). The odds ratio for AD in individuals with either one or two ε4 alleles was 5.22 (95% confidence interval: 2.32- 11.70). The polymorphism within the region composing intron 3' to exon 8 of the PS-1 gene showed a similar distribution between AD patients and controls. This is the first study on the intronic polymorphism of the PS-1 gene in Chinese. Our results support an association between apoE ε4 and AD in Chinese, but not between the intronic polymorphism of the PS-1 gene and AD. However, the allele frequency of apo-E ε4 among Chinese is lower than that among Caucasians. The interaction between apo-E and PS-1 genotypes is still unclear.

Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalJournal of the Neurological Sciences
Volume157
Issue number2
DOIs
Publication statusPublished - May 7 1998
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Chinese
  • Dementia
  • Genetics
  • Presenilin- 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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