TY - JOUR
T1 - Association of air pollution exposure with exercise-induced oxygen desaturation in COPD
AU - Lee, Kang Yun
AU - Wu, Sheng Ming
AU - Kou, Hsiao Yun
AU - Chen, Kuan Yuan
AU - Chuang, Hsiao Chi
AU - Feng, Po Hao
AU - Chung, Kian Fan
AU - Ito, Kazuhiro
AU - Chen, Tzu Tao
AU - Sun, Wei Lun
AU - Liu, Wen Te
AU - Tseng, Chien Hua
AU - Ho, Shu Chuan
N1 - Funding Information:
This study was funded by the Ministry of Science and Technology (108-2314-B-038-113-MY3), the Ministry of Education of Taiwan (DP2-110-21121-01-T-01-05), and Taipei Medical University-Shuang Ho Hospital (110TMU-SHH-05).
Funding Information:
The authors wish to thank the Department of Radiology at Shuang Ho Hospital for technical assistance with this research. KF Chung is a Visiting Professor at Taipei Medical University.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O2 desaturation during exercise in COPD patients with emphysema is unclear. Our aims were to estimate the prevalence of O2 desaturation during exercise in patients with COPD, and determine the association of exposure to air pollution with exercise-induced desaturation (EID), the degree of emphysema, and dynamic hyperinflation (DH). Methods: We assessed the effects of 10-year prior to the HRCT assessment and 7 days prior to the six-minute walking test exposure to particulate matter with an aerodynamic diameter of < 10 µm (PM10) or of < 2.5 µM (PM2.5), nitrogen dioxide (NO2), and ozone (O3) in patients with emphysema in this retrospective cohort study. EID was defined as a nadir standard pulse oximetry (SpO2) level of < 90% or a delta (△)SpO2 level of ≥ 4%. Ambient air pollutant (PM2.5, PM10, O3, and NO2) data were obtained from Taiwan Environmental Protection Administration (EPA) air-monitoring stations, usually within 10 km to each participant’s home address. Results: We recruited 141 subjects with emphysema. 41.1% of patients with emphysema exhibited EID, and patients with EID had more dyspnea, worse lung function, more severe emphysema, more frequent acute exacerbations, managed a shorter walking distance, had DH, and greater long-term exposure to air pollution than those without EID. We observed that levels of 10-year concentrations of PM10, PM2.5, and NO2 were significantly associated with EID, PM10 and PM2.5 were associated with the severity of emphysema, and associated with DH in patients with emphysema. In contrast, short-term exposure did not have any effect on patients. Conclusion: Long-term exposure to ambient PM10, PM2.5 and NO2, but not O3, was associated with EID.
AB - Background: There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O2 desaturation during exercise in COPD patients with emphysema is unclear. Our aims were to estimate the prevalence of O2 desaturation during exercise in patients with COPD, and determine the association of exposure to air pollution with exercise-induced desaturation (EID), the degree of emphysema, and dynamic hyperinflation (DH). Methods: We assessed the effects of 10-year prior to the HRCT assessment and 7 days prior to the six-minute walking test exposure to particulate matter with an aerodynamic diameter of < 10 µm (PM10) or of < 2.5 µM (PM2.5), nitrogen dioxide (NO2), and ozone (O3) in patients with emphysema in this retrospective cohort study. EID was defined as a nadir standard pulse oximetry (SpO2) level of < 90% or a delta (△)SpO2 level of ≥ 4%. Ambient air pollutant (PM2.5, PM10, O3, and NO2) data were obtained from Taiwan Environmental Protection Administration (EPA) air-monitoring stations, usually within 10 km to each participant’s home address. Results: We recruited 141 subjects with emphysema. 41.1% of patients with emphysema exhibited EID, and patients with EID had more dyspnea, worse lung function, more severe emphysema, more frequent acute exacerbations, managed a shorter walking distance, had DH, and greater long-term exposure to air pollution than those without EID. We observed that levels of 10-year concentrations of PM10, PM2.5, and NO2 were significantly associated with EID, PM10 and PM2.5 were associated with the severity of emphysema, and associated with DH in patients with emphysema. In contrast, short-term exposure did not have any effect on patients. Conclusion: Long-term exposure to ambient PM10, PM2.5 and NO2, but not O3, was associated with EID.
KW - Air pollution
KW - COPD
KW - Dynamic hyperinflation (DH)
KW - Emphysema
KW - Exercise-induced desaturation (EID)
KW - Low attenuation area (LAA)
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U2 - 10.1186/s12931-022-02000-1
DO - 10.1186/s12931-022-02000-1
M3 - Article
C2 - 35361214
AN - SCOPUS:85127413261
SN - 1465-9921
VL - 23
JO - Respiratory Research
JF - Respiratory Research
IS - 1
M1 - 77
ER -