TY - JOUR
T1 - Association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer
T2 - A meta-analysis
AU - Su, Chih Ming
AU - Chen, Mei-Chieh
AU - Lin, I-Chan
AU - Chen, Hsin An
AU - Huang, Ming-Te
AU - Wu, Chih-Hsiung
AU - Shen, Kun Hung
AU - Wang, Yuan-Hung
PY - 2014/6
Y1 - 2014/6
N2 - Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 % confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR=1.218, 95 % CI=1.067-1.392, P=0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR=1.269, 95 % CI=1.069-1.506, P=0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR=1.428, 95 % CI=1.079-1.890, P=0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.
AB - Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 % confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR=1.218, 95 % CI=1.067-1.392, P=0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR=1.269, 95 % CI=1.069-1.506, P=0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR=1.428, 95 % CI=1.079-1.890, P=0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.
KW - Bladder cancer
KW - Meta-analysis
KW - Polymorphisms
KW - Sulfotransferase 1A1
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U2 - 10.1007/s13277-014-1954-5
DO - 10.1007/s13277-014-1954-5
M3 - Article
C2 - 24763827
AN - SCOPUS:84904875116
SN - 1010-4283
VL - 35
SP - 7147
EP - 7153
JO - Tumor Biology
JF - Tumor Biology
IS - 7
ER -
