Association Between the Prostate-specific Antigen Gene and the Risk of Prostate Cancer in a Taiwanese Population

Objective: We attempted to determine the association between a G/A polymorphism at position 158 of the prostate-specific antigen (PSA) gene and the risk of prostate cancer in Taiwanese men. Materials and Methods: We genotyped 149 prostate cancer patients and 176 healthy controls. Logistic regression was used to estimate the odd ratios (ORs) and confidence intervals (CIs). Results: The G allele was more frequent than the A allele in both cases and in controls. The A allele was not associated with a significantly higher risk of prostate cancer (odds ratio [OR] = 1.17, confidence interval = 0.78-1.76). GA (OR = 1.18) and AA (OR = 1.19) genotypes were not associated with a significantly higher risk of prostate cancer. In an analysis by disease aggressiveness, aggressive disease had a higher OR than that for nonaggressive disease (1.38 vs. 0.77); however, these associations were not statistically significant. Conclusions: No association was found between G/A polymorphism and the risk of prostate cancer. Larger studies are necessary to determine whether the A allele is associated with aggressive prostate cancer.