TY - JOUR
T1 - Association Between the Prostate-specific Antigen Gene and the Risk of Prostate Cancer in a Taiwanese Population
AU - Chen, Marcelo
AU - Huang, Yu Chuen
AU - Yang, Stone
AU - Chen, Yi Ming Arthur
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Objective: We attempted to determine the association between a G/A polymorphism at position 158 of the prostate-specific antigen (PSA) gene and the risk of prostate cancer in Taiwanese men. Materials and Methods: We genotyped 149 prostate cancer patients and 176 healthy controls. Logistic regression was used to estimate the odd ratios (ORs) and confidence intervals (CIs). Results: The G allele was more frequent than the A allele in both cases and in controls. The A allele was not associated with a significantly higher risk of prostate cancer (odds ratio [OR] = 1.17, confidence interval = 0.78-1.76). GA (OR = 1.18) and AA (OR = 1.19) genotypes were not associated with a significantly higher risk of prostate cancer. In an analysis by disease aggressiveness, aggressive disease had a higher OR than that for nonaggressive disease (1.38 vs. 0.77); however, these associations were not statistically significant. Conclusions: No association was found between G/A polymorphism and the risk of prostate cancer. Larger studies are necessary to determine whether the A allele is associated with aggressive prostate cancer.
AB - Objective: We attempted to determine the association between a G/A polymorphism at position 158 of the prostate-specific antigen (PSA) gene and the risk of prostate cancer in Taiwanese men. Materials and Methods: We genotyped 149 prostate cancer patients and 176 healthy controls. Logistic regression was used to estimate the odd ratios (ORs) and confidence intervals (CIs). Results: The G allele was more frequent than the A allele in both cases and in controls. The A allele was not associated with a significantly higher risk of prostate cancer (odds ratio [OR] = 1.17, confidence interval = 0.78-1.76). GA (OR = 1.18) and AA (OR = 1.19) genotypes were not associated with a significantly higher risk of prostate cancer. In an analysis by disease aggressiveness, aggressive disease had a higher OR than that for nonaggressive disease (1.38 vs. 0.77); however, these associations were not statistically significant. Conclusions: No association was found between G/A polymorphism and the risk of prostate cancer. Larger studies are necessary to determine whether the A allele is associated with aggressive prostate cancer.
KW - Genetic polymorphism
KW - Prostate cancer
KW - Prostate-specific antigen gene
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U2 - 10.1016/S1879-5226(11)60005-5
DO - 10.1016/S1879-5226(11)60005-5
M3 - Article
AN - SCOPUS:79954517342
SN - 1879-5226
VL - 22
SP - 28
EP - 31
JO - Urological Science
JF - Urological Science
IS - 1
ER -
