Methods: This case-control study identified 1,977 subjects with Bell’s palsy as cases and 5,931 sex- and age-matched subjects without Bell’s palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95 % confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell’s palsy were further analyzed.

Background: Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity.

Objective: This study aimed to evaluate the association between statin use and Bell’s palsy using a population-based health insurance database.

Results: By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4 %, p 

Conclusions: Our present data suggest a potential association between regular statin use and Bell’s palsy.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalDrug Safety
Issue number9
Publication statusPublished - Sept 2014

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Pharmacology (medical)


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