Abstract
Methods: This case-control study identified 1,977 subjects with Bell’s palsy as cases and 5,931 sex- and age-matched subjects without Bell’s palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95 % confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell’s palsy were further analyzed.
Background: Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity.
Objective: This study aimed to evaluate the association between statin use and Bell’s palsy using a population-based health insurance database.
Results: By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4 %, p
Conclusions: Our present data suggest a potential association between regular statin use and Bell’s palsy.
| Original language | English |
|---|---|
| Pages (from-to) | 735-742 |
| Number of pages | 8 |
| Journal | Drug Safety |
| Volume | 37 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sept 2014 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology
- Pharmacology (medical)