TY - JOUR
T1 - Association between sleep disorder and atrial fibrillation
T2 - A nationwide population-based cohort study
AU - Chen, Chun Chao
AU - Lin, Cheng Hsin
AU - Yang, Tsung Yeh
AU - Wang, Ta Jung
AU - Li, Shao Jung
AU - Fang, Yu Ann
AU - Chen, Tzu Jung
AU - Tzeng, Huey En
AU - Chiu, Chun Chih
AU - Hao, Wen Rui
AU - Lu, Meng Ying
AU - Liu, Ju Chi
N1 - Funding Information:
This work was financially supported of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan , and Taipei Medical University-National Taiwan University Hospital Joint Research Program ,( 111-TMU085 ).
Publisher Copyright:
© 2022
PY - 2022/8
Y1 - 2022/8
N2 - Objectives: Sleep disorder (SD), especially sleep apnea, and its effect on atrial fibrillation (AF) are gathering attention. However, other SDs may also play an essential role in AF. The aim of the study is to investigate the effects of other SDs on the risk of atrial fibrillation development. Methods: This study investigated the risk of AF in people diagnosed with SD compared with that in age and sex-matched unaffected individuals. This longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) of individuals diagnosed with SD from January 1, 2001, to December 31, 2012. Results: The sample consisted of 193,288 people with the SD, which include of 4406 people with sleep apnea, 73,704 people with insomnia, 107,395 people with sleep disturbance, 7,783 people with other SD, and 193,288 matched controls. A Cox proportional hazard regression was used to compute the risk of AF in people with SD and subgroup of SD, relative to that in people without SD. The AF incidences were 1.21-fold higher (95% CI 1.15–1.27) in the SD cohort, 1.19-fold higher (95% CI 0.91–1.56) in the sleep apnea cohort, 1.26-fold higher (95% CI 1.19–1.34) in the insomnia cohort, 1.15-fold higher (95% CI 1.08–1.22) in the sleep disturbance cohort, and 1.30-fold higher (95% CI 1.11–1.53) in other SDs, than in the control cohort, after age, sex, and comorbidities were adjusted. Conclusions: This nationwide population-based cohort study indicates a strong relationship between SD and incident AF, and insomnia has a higher impact on AF compared with other SD.
AB - Objectives: Sleep disorder (SD), especially sleep apnea, and its effect on atrial fibrillation (AF) are gathering attention. However, other SDs may also play an essential role in AF. The aim of the study is to investigate the effects of other SDs on the risk of atrial fibrillation development. Methods: This study investigated the risk of AF in people diagnosed with SD compared with that in age and sex-matched unaffected individuals. This longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) of individuals diagnosed with SD from January 1, 2001, to December 31, 2012. Results: The sample consisted of 193,288 people with the SD, which include of 4406 people with sleep apnea, 73,704 people with insomnia, 107,395 people with sleep disturbance, 7,783 people with other SD, and 193,288 matched controls. A Cox proportional hazard regression was used to compute the risk of AF in people with SD and subgroup of SD, relative to that in people without SD. The AF incidences were 1.21-fold higher (95% CI 1.15–1.27) in the SD cohort, 1.19-fold higher (95% CI 0.91–1.56) in the sleep apnea cohort, 1.26-fold higher (95% CI 1.19–1.34) in the insomnia cohort, 1.15-fold higher (95% CI 1.08–1.22) in the sleep disturbance cohort, and 1.30-fold higher (95% CI 1.11–1.53) in other SDs, than in the control cohort, after age, sex, and comorbidities were adjusted. Conclusions: This nationwide population-based cohort study indicates a strong relationship between SD and incident AF, and insomnia has a higher impact on AF compared with other SD.
KW - Atrial fibrillation
KW - Insomnia
KW - Sleep apnea
KW - Sleep disorder
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U2 - 10.1016/j.sleep.2022.05.002
DO - 10.1016/j.sleep.2022.05.002
M3 - Article
C2 - 35597072
AN - SCOPUS:85130902763
SN - 1389-9457
VL - 96
SP - 50
EP - 56
JO - Sleep Medicine
JF - Sleep Medicine
ER -