TY - JOUR
T1 - Association between Scale-Free Brain Dynamics and Behavioral Performance
T2 - Functional MRI Study in Resting State and Face Processing Task
AU - Kasagi, Masato
AU - Huang, Zirui
AU - Narita, Kosuke
AU - Shitara, Hitoshi
AU - Motegi, Tomokazu
AU - Suzuki, Yusuke
AU - Fujihara, Kazuyuki
AU - Tanabe, Sean
AU - Kosaka, Hirotaka
AU - Ujita, Koichi
AU - Fukuda, Masato
AU - Northoff, Georg
N1 - Funding Information:
Kosuke Narita acknowledges the support from JSPS KAKENHI Grant nos. JP 23591695 and 15KK0295, and Georg Northoff acknowledges the support from CRC, the University of Ottawa Brain and Mind Research Institute, CIHR, and the Michael Smith Foundation.
Publisher Copyright:
© 2017 Masato Kasagi et al.
PY - 2017
Y1 - 2017
N2 - The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. Power laws are well documented in nature in general, particularly in the brain. Some previous fMRI studies have demonstrated a lower PLE during cognitive-task-evoked activity than during resting state activity. However, PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear. In this functional fMRI study in the resting state and face processing + control task, we investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task. We found that (1) face discrimination-induced BOLD signal changes in the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), amygdala, and fusiform face area; (2) PLE significantly decreased during task-evoked activity specifically in mPFC compared with resting state activity; (3) most importantly, in mPFC, mRT significantly negatively correlated with both resting state PLE and the resting-task PLE difference. These results may lead to a better understanding of the associations between task performance parameters (e.g., mRT) and the scale-free dynamics of spontaneous and task-evoked brain activities.
AB - The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. Power laws are well documented in nature in general, particularly in the brain. Some previous fMRI studies have demonstrated a lower PLE during cognitive-task-evoked activity than during resting state activity. However, PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear. In this functional fMRI study in the resting state and face processing + control task, we investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task. We found that (1) face discrimination-induced BOLD signal changes in the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), amygdala, and fusiform face area; (2) PLE significantly decreased during task-evoked activity specifically in mPFC compared with resting state activity; (3) most importantly, in mPFC, mRT significantly negatively correlated with both resting state PLE and the resting-task PLE difference. These results may lead to a better understanding of the associations between task performance parameters (e.g., mRT) and the scale-free dynamics of spontaneous and task-evoked brain activities.
UR - http://www.scopus.com/inward/record.url?scp=85042191828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042191828&partnerID=8YFLogxK
U2 - 10.1155/2017/2824615
DO - 10.1155/2017/2824615
M3 - Article
C2 - 29430081
AN - SCOPUS:85042191828
SN - 0953-4180
VL - 2017
JO - Behavioural Neurology
JF - Behavioural Neurology
M1 - 2824615
ER -