TY - JOUR
T1 - Association between Scale-Free Brain Dynamics and Behavioral Performance
T2 - Functional MRI Study in Resting State and Face Processing Task
AU - Kasagi, Masato
AU - Huang, Zirui
AU - Narita, Kosuke
AU - Shitara, Hitoshi
AU - Motegi, Tomokazu
AU - Suzuki, Yusuke
AU - Fujihara, Kazuyuki
AU - Tanabe, Sean
AU - Kosaka, Hirotaka
AU - Ujita, Koichi
AU - Fukuda, Masato
AU - Northoff, Georg
N1 - Publisher Copyright:
© 2017 Masato Kasagi et al.
PY - 2017
Y1 - 2017
N2 - The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. Power laws are well documented in nature in general, particularly in the brain. Some previous fMRI studies have demonstrated a lower PLE during cognitive-task-evoked activity than during resting state activity. However, PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear. In this functional fMRI study in the resting state and face processing + control task, we investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task. We found that (1) face discrimination-induced BOLD signal changes in the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), amygdala, and fusiform face area; (2) PLE significantly decreased during task-evoked activity specifically in mPFC compared with resting state activity; (3) most importantly, in mPFC, mRT significantly negatively correlated with both resting state PLE and the resting-task PLE difference. These results may lead to a better understanding of the associations between task performance parameters (e.g., mRT) and the scale-free dynamics of spontaneous and task-evoked brain activities.
AB - The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. Power laws are well documented in nature in general, particularly in the brain. Some previous fMRI studies have demonstrated a lower PLE during cognitive-task-evoked activity than during resting state activity. However, PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear. In this functional fMRI study in the resting state and face processing + control task, we investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task. We found that (1) face discrimination-induced BOLD signal changes in the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), amygdala, and fusiform face area; (2) PLE significantly decreased during task-evoked activity specifically in mPFC compared with resting state activity; (3) most importantly, in mPFC, mRT significantly negatively correlated with both resting state PLE and the resting-task PLE difference. These results may lead to a better understanding of the associations between task performance parameters (e.g., mRT) and the scale-free dynamics of spontaneous and task-evoked brain activities.
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U2 - 10.1155/2017/2824615
DO - 10.1155/2017/2824615
M3 - Article
C2 - 29430081
AN - SCOPUS:85042191828
SN - 0953-4180
VL - 2017
JO - Behavioural Neurology
JF - Behavioural Neurology
M1 - 2824615
ER -