Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention

Su Chan Chen; Ya Ling Yang; Cheng Hsueh Wu; Shao Sung Huang; Wan Leong Chan; Shing Jong Lin; Chia Yu Chou; Jaw Wen Chen; Ju Pin Pan; Min Ji Charng; Ying Hwa Chen; Tao Cheng Wu; Tse Min Lu; Pai Feng Hsu; Po Hsun Huang; Hao Min Cheng; Chin Chou Huang; Shih Hsien Sung; Yenn Jiang Lin; Hsin Bang Leu

doi:10.3390/nu12051295

Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention

Su Chan Chen, Ya Ling Yang, Cheng Hsueh Wu, Shao Sung Huang, Wan Leong Chan, Shing Jong Lin, Chia Yu Chou, Jaw Wen Chen, Ju Pin Pan, Min Ji Charng, Ying Hwa Chen, Tao Cheng Wu, Tse Min Lu, Pai Feng Hsu, Po Hsun Huang, Hao Min Cheng, Chin Chou Huang, Shih Hsien Sung, Yenn Jiang Lin, Hsin Bang Leu

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Background: Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. Methods: We recruited a cohort of 3118 patients with CAD undergoing percutaneous coronary intervention (PCI) from 2005 to 2015. Nutritional status was evaluated using the CONUT score, with higher scores reflecting worse nutritional status. Results: After adjustment for comorbidities and medication, an increased CONUT score was independently associated with a higher risk of acute myocardial infarction (AMI) (HR: 1.13; 95% CI: 1.03–1.24), cardiovascular (CV) death (HR: 1.18; 95% CI: 1.07–1.30), congestive heart failure (CHF) (HR: 1.11; 95% CI: 1.04–1.18), a major adverse cardiovascular event (MACE) (HR: 1.14; 95% CI: 1.07–1.22), and total CV events (HR: 1.11; 95% CI: 1.07–1.15). The subgroup analyses demonstrated that the association of the CONUT score existed independently of other established cardiovascular risk factors. In addition, CONUT significantly improved risk stratification for myocardial infarction (MI), cardiac death, CHF, MACEs and total CV events compared to conventional risk factors in CAD patients by the significant increase in the C-index (p < 0.05) and reclassification risk categories in cardiac death and MACEs. Conclusions The CONUT score improved the risk prediction of adverse events compared to traditional risk factors in CAD patients after percutaneous coronary intervention (PCI).

Original language	English
Article number	1295
Journal	Nutrients
Volume	12
Issue number	5
DOIs	https://doi.org/10.3390/nu12051295
Publication status	Published - May 2020
Externally published	Yes

Keywords

Controlling Nutritional Status (CONUT) score
Coronary artery disease
Nutrition
Percutaneous coronary intervention
Risk stratification

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu12051295

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Chen, S. C., Yang, Y. L., Wu, C. H., Huang, S. S., Chan, W. L., Lin, S. J., Chou, C. Y., Chen, J. W., Pan, J. P., Charng, M. J., Chen, Y. H., Wu, T. C., Lu, T. M., Hsu, P. F., Huang, P. H., Cheng, H. M., Huang, C. C., Sung, S. H., Lin, Y. J., & Leu, H. B. (2020). Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention. Nutrients, 12(5), Article 1295. https://doi.org/10.3390/nu12051295

Chen, SC, Yang, YL, Wu, CH, Huang, SS, Chan, WL, Lin, SJ, Chou, CY, Chen, JW, Pan, JP, Charng, MJ, Chen, YH, Wu, TC, Lu, TM, Hsu, PF, Huang, PH, Cheng, HM, Huang, CC, Sung, SH, Lin, YJ & Leu, HB 2020, 'Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention', Nutrients, vol. 12, no. 5, 1295. https://doi.org/10.3390/nu12051295

@article{16bf54f66731422b8058ee4991770b9c,

title = "Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention",

abstract = "Background: Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. Methods: We recruited a cohort of 3118 patients with CAD undergoing percutaneous coronary intervention (PCI) from 2005 to 2015. Nutritional status was evaluated using the CONUT score, with higher scores reflecting worse nutritional status. Results: After adjustment for comorbidities and medication, an increased CONUT score was independently associated with a higher risk of acute myocardial infarction (AMI) (HR: 1.13; 95% CI: 1.03–1.24), cardiovascular (CV) death (HR: 1.18; 95% CI: 1.07–1.30), congestive heart failure (CHF) (HR: 1.11; 95% CI: 1.04–1.18), a major adverse cardiovascular event (MACE) (HR: 1.14; 95% CI: 1.07–1.22), and total CV events (HR: 1.11; 95% CI: 1.07–1.15). The subgroup analyses demonstrated that the association of the CONUT score existed independently of other established cardiovascular risk factors. In addition, CONUT significantly improved risk stratification for myocardial infarction (MI), cardiac death, CHF, MACEs and total CV events compared to conventional risk factors in CAD patients by the significant increase in the C-index (p < 0.05) and reclassification risk categories in cardiac death and MACEs. Conclusions The CONUT score improved the risk prediction of adverse events compared to traditional risk factors in CAD patients after percutaneous coronary intervention (PCI).",

keywords = "Controlling Nutritional Status (CONUT) score, Coronary artery disease, Nutrition, Percutaneous coronary intervention, Risk stratification",

author = "Chen, {Su Chan} and Yang, {Ya Ling} and Wu, {Cheng Hsueh} and Huang, {Shao Sung} and Chan, {Wan Leong} and Lin, {Shing Jong} and Chou, {Chia Yu} and Chen, {Jaw Wen} and Pan, {Ju Pin} and Charng, {Min Ji} and Chen, {Ying Hwa} and Wu, {Tao Cheng} and Lu, {Tse Min} and Hsu, {Pai Feng} and Huang, {Po Hsun} and Cheng, {Hao Min} and Huang, {Chin Chou} and Sung, {Shih Hsien} and Lin, {Yenn Jiang} and Leu, {Hsin Bang}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = may,

doi = "10.3390/nu12051295",

language = "English",

volume = "12",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention

AU - Chen, Su Chan

AU - Yang, Ya Ling

AU - Wu, Cheng Hsueh

AU - Huang, Shao Sung

AU - Chan, Wan Leong

AU - Lin, Shing Jong

AU - Chou, Chia Yu

AU - Chen, Jaw Wen

AU - Pan, Ju Pin

AU - Charng, Min Ji

AU - Chen, Ying Hwa

AU - Wu, Tao Cheng

AU - Lu, Tse Min

AU - Hsu, Pai Feng

AU - Huang, Po Hsun

AU - Cheng, Hao Min

AU - Huang, Chin Chou

AU - Sung, Shih Hsien

AU - Lin, Yenn Jiang

AU - Leu, Hsin Bang

PY - 2020/5

Y1 - 2020/5

N2 - Background: Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. Methods: We recruited a cohort of 3118 patients with CAD undergoing percutaneous coronary intervention (PCI) from 2005 to 2015. Nutritional status was evaluated using the CONUT score, with higher scores reflecting worse nutritional status. Results: After adjustment for comorbidities and medication, an increased CONUT score was independently associated with a higher risk of acute myocardial infarction (AMI) (HR: 1.13; 95% CI: 1.03–1.24), cardiovascular (CV) death (HR: 1.18; 95% CI: 1.07–1.30), congestive heart failure (CHF) (HR: 1.11; 95% CI: 1.04–1.18), a major adverse cardiovascular event (MACE) (HR: 1.14; 95% CI: 1.07–1.22), and total CV events (HR: 1.11; 95% CI: 1.07–1.15). The subgroup analyses demonstrated that the association of the CONUT score existed independently of other established cardiovascular risk factors. In addition, CONUT significantly improved risk stratification for myocardial infarction (MI), cardiac death, CHF, MACEs and total CV events compared to conventional risk factors in CAD patients by the significant increase in the C-index (p < 0.05) and reclassification risk categories in cardiac death and MACEs. Conclusions The CONUT score improved the risk prediction of adverse events compared to traditional risk factors in CAD patients after percutaneous coronary intervention (PCI).

AB - Background: Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. Methods: We recruited a cohort of 3118 patients with CAD undergoing percutaneous coronary intervention (PCI) from 2005 to 2015. Nutritional status was evaluated using the CONUT score, with higher scores reflecting worse nutritional status. Results: After adjustment for comorbidities and medication, an increased CONUT score was independently associated with a higher risk of acute myocardial infarction (AMI) (HR: 1.13; 95% CI: 1.03–1.24), cardiovascular (CV) death (HR: 1.18; 95% CI: 1.07–1.30), congestive heart failure (CHF) (HR: 1.11; 95% CI: 1.04–1.18), a major adverse cardiovascular event (MACE) (HR: 1.14; 95% CI: 1.07–1.22), and total CV events (HR: 1.11; 95% CI: 1.07–1.15). The subgroup analyses demonstrated that the association of the CONUT score existed independently of other established cardiovascular risk factors. In addition, CONUT significantly improved risk stratification for myocardial infarction (MI), cardiac death, CHF, MACEs and total CV events compared to conventional risk factors in CAD patients by the significant increase in the C-index (p < 0.05) and reclassification risk categories in cardiac death and MACEs. Conclusions The CONUT score improved the risk prediction of adverse events compared to traditional risk factors in CAD patients after percutaneous coronary intervention (PCI).

KW - Controlling Nutritional Status (CONUT) score

KW - Coronary artery disease

KW - Nutrition

KW - Percutaneous coronary intervention

KW - Risk stratification

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U2 - 10.3390/nu12051295

DO - 10.3390/nu12051295

M3 - Article

C2 - 32370130

AN - SCOPUS:85084329172

SN - 2072-6643

VL - 12

JO - Nutrients

JF - Nutrients

IS - 5

M1 - 1295

ER -

Association between preoperative nutritional status and clinical outcomes of patients with coronary artery disease undergoing percutaneous coronary intervention

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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