Abstract
Background: This study aimed to evaluate the association between pioglitazone use and the occurrence of head and neck cancer. Methods: Data for this case-control study were retrieved from the Taiwan National Health Insurance Research Database. A total of 21 464 diabetic patients newly diagnosed with head and neck cancers were identified. We used propensity score matching to select 64 392 comparison patients (3:1 ratio). Multiple logistic regression modeling was used to examine the association of head and neck cancer with pioglitazone use in the 5 years preceding the cancer diagnosis. Results: Bivariate analysis showed a significant difference in the prevalence of prior using pioglitazone between cases and controls (19.3% vs 18.5%, P <.001) was observed. Multiple regression analysis showed adjusted odds of pioglitazone use of 1.06 (95% CI: 1.02-1.10) among cases relative to controls. Conclusions: Prior pioglitazone use was associated with oral cavity cancer.
Original language | English |
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Pages (from-to) | 653-659 |
Number of pages | 7 |
Journal | Head and Neck |
Volume | 42 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 1 2020 |
Keywords
- diabetes
- epidemiology
- head and neck cancer
- oral cavity cancer
- pioglitazone
ASJC Scopus subject areas
- Otorhinolaryngology