Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population-based cohort study

Chao Yueh Fan; Yee Min Jen; Yuan Chih Su; Hsing Lung Chao; Chun Shu Lin; Wen Yen Huang; Miao Jung Lin; Chia Hung Kao

doi:10.1002/hed.25177

Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population-based cohort study

Chao Yueh Fan, Yee Min Jen, Yuan Chih Su, Hsing Lung Chao, Chun Shu Lin, Wen Yen Huang, Miao Jung Lin, Chia Hung Kao

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). Methods: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC. Results: The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85-4.09; P <.001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07-2.7; P =.03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17-2.06; P =.002). Conclusion: The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.

Original language	English
Pages (from-to)	1977-1985
Number of pages	9
Journal	Head and Neck
Volume	40
Issue number	9
DOIs	https://doi.org/10.1002/hed.25177
Publication status	Published - Sept 2018
Externally published	Yes

Keywords

chemotherapy
cohort study
nasopharyngeal carcinoma
optic neuropathy
radiotherapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25177

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title = "Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population-based cohort study",

abstract = "Background: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). Methods: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC. Results: The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85-4.09; P <.001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07-2.7; P =.03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17-2.06; P =.002). Conclusion: The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.",

keywords = "chemotherapy, cohort study, nasopharyngeal carcinoma, optic neuropathy, radiotherapy",

author = "Fan, {Chao Yueh} and Jen, {Yee Min} and Su, {Yuan Chih} and Chao, {Hsing Lung} and Lin, {Chun Shu} and Huang, {Wen Yen} and Lin, {Miao Jung} and Kao, {Chia Hung}",

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year = "2018",

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doi = "10.1002/hed.25177",

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volume = "40",

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T2 - A population-based cohort study

AU - Fan, Chao Yueh

AU - Jen, Yee Min

AU - Su, Yuan Chih

AU - Chao, Hsing Lung

AU - Lin, Chun Shu

AU - Huang, Wen Yen

AU - Lin, Miao Jung

AU - Kao, Chia Hung

PY - 2018/9

Y1 - 2018/9

N2 - Background: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). Methods: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC. Results: The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85-4.09; P <.001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07-2.7; P =.03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17-2.06; P =.002). Conclusion: The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.

AB - Background: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). Methods: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC. Results: The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85-4.09; P <.001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07-2.7; P =.03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17-2.06; P =.002). Conclusion: The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.

KW - chemotherapy

KW - cohort study

KW - nasopharyngeal carcinoma

KW - optic neuropathy

KW - radiotherapy

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Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population-based cohort study

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Keywords

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