Association between mycoplasma pneumonia and increased risk of ischemic stroke: A nationwide study

Chia Hung Chiang, Chin Chou Huang, Wan Leong Chan, Yu Chun Chen, Tzeng Ji Chen, Shing Jong Lin, Jaw Wen Chen, Hsin Bang Leu

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Background and Purpose-Infections have been hypothesized to play a role in vascular disease. The association between Mycoplasma pneumoniae (MP) infection and ischemic stroke remained undetermined. Methods-A total of 1094 patients with MP infection were enrolled as the study group and compared with 5168 sex-, age-, and comorbidity-matched subjects without MP, to be followed up prospectively from January 2003 to December 2007 for development of ischemic stroke. RESULTS-: During a maximum 5-year follow-up period, 49 patients with ischemic stroke were identified. Subjects with MP infection were significantly associated with increased risk of ischemic stroke compared with controls (1.10% versus 0.72%, respectively; P=0.01). The logrank test showed that patients with MP had significantly higher incidence of stroke development than did those without MP (P=0.046). After Cox model adjustment for risk factors and comorbidities, MP infection was still independently associated with increased risk of stroke (hazard ratio [HR], 2.07; 95% CI, 1.05-4.03). Conclusions-We conclude that MP infection is independently associated with risk of subsequent ischemic stroke development.

Original languageEnglish
Pages (from-to)2940-2943
Number of pages4
JournalStroke
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Keywords

  • inflammation
  • ischemic stroke
  • mycoplasma pneumoniae

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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