Association between migraine and irritable bowel syndrome: A population-based retrospective cohort study

C. I. Lau, C. C. Lin, W. H. Chen, Han-Cheng Wang, C. H. Kao

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Background and purpose: Migraine and irritable bowel syndrome (IBS) share many similarities characterized by their epidemiology, periodic pain, lack of definable organic causes, trigger factors, comorbidities and proposed pathophysiology. In this retrospective case-control study, the association between migraine and IBS was investigated using a nationwide population-based database in Taiwan. Methods: The data were retrieved from the National Health Insurance Research Database (NHIRD) of Taiwan. In all, 14 117 newly diagnosed migraine cases were identified in a subset of the NHIRD and 56 468 migraine-free individuals were randomly selected as the comparison cohort. The multivariate Cox proportional hazards regression model was used to explore the risk of IBS in migraine sufferers after adjusting for demographic characteristics and comorbidities. Results: After adjusting for the covariates, the incidence of IBS was 1.95-fold higher in the migraine cohort than in the comparison cohort (73.87 vs. 30.14 per 10 000 person-years). The adjusted cumulative incidence of IBS was also higher in the migraine group than in the control group in the follow-up years (log-rank test, P 

Original languageEnglish
Pages (from-to)1198-1204
Number of pages7
JournalEuropean Journal of Neurology
Issue number9
Publication statusPublished - 2014


  • Irritable bowel syndrome
  • Migraine
  • National Health Insurance Research Database
  • Retrospective cohort study

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Association between migraine and irritable bowel syndrome: A population-based retrospective cohort study'. Together they form a unique fingerprint.

Cite this