TY - JOUR
T1 - Association between metabolic syndrome and oral pre-malignancy
T2 - A community- and population-based study (KCIS No. 28)
AU - Yen, Amy Ming Fang
AU - Chen, Sam Li Sheng
AU - Chiu, Sherry Yueh Hsia
AU - Chen, Hsiu Hsi
PY - 2011/7
Y1 - 2011/7
N2 - To elucidate the effect of metabolic syndrome (MetS) on oral pre-malignancy (OPM) and also to examine whether the effect is independent of areca nut chewing. We enrolled a total of 79,940 subjects aged 20 years or older undergoing both oral mucous examination and health check-up for MetS within the Keelung Community-based Integrated Screening program between 2003 and 2008. We identified 368 leukoplakia, 72 erythroleukoplakia, and 69 oral submucous fibrosis. The multi-variable logistic regression was used to assess the association between MetS and OPM with adjustment of age, gender, areca nut chewing, smoking, and alcohol drinking. Subjects with MetS were at increased risk for OPM (adjusted odds ratio (aOR) = 1.68, 95% confidence interval (CI): 1.39-2.04) compared with those without MetS after taking all explanatory factors into account. Among the five components of MetS, subjects with hypertriglyceride (aOR = 1.43, 95% CI: 1.17-1.75) and hyperglycemia (aOR = 1.30, 95% CI: 1.02-1.67) had higher risk of presenting OPM compared with those within normal ranges. The association between MetS and OPM still persisted even in non-chewers (aOR = 1.85, 95% CI: 1.42-2.40) while other risk factors were controlled. We demonstrate a positive association between MetS and OPM, which is independent of areca nut chewing and other confounding factors. This finding provides an insight into a new direction of preventing OPM in contrast to conventional viewpoint focusing on the most important factor of area nut chewing.
AB - To elucidate the effect of metabolic syndrome (MetS) on oral pre-malignancy (OPM) and also to examine whether the effect is independent of areca nut chewing. We enrolled a total of 79,940 subjects aged 20 years or older undergoing both oral mucous examination and health check-up for MetS within the Keelung Community-based Integrated Screening program between 2003 and 2008. We identified 368 leukoplakia, 72 erythroleukoplakia, and 69 oral submucous fibrosis. The multi-variable logistic regression was used to assess the association between MetS and OPM with adjustment of age, gender, areca nut chewing, smoking, and alcohol drinking. Subjects with MetS were at increased risk for OPM (adjusted odds ratio (aOR) = 1.68, 95% confidence interval (CI): 1.39-2.04) compared with those without MetS after taking all explanatory factors into account. Among the five components of MetS, subjects with hypertriglyceride (aOR = 1.43, 95% CI: 1.17-1.75) and hyperglycemia (aOR = 1.30, 95% CI: 1.02-1.67) had higher risk of presenting OPM compared with those within normal ranges. The association between MetS and OPM still persisted even in non-chewers (aOR = 1.85, 95% CI: 1.42-2.40) while other risk factors were controlled. We demonstrate a positive association between MetS and OPM, which is independent of areca nut chewing and other confounding factors. This finding provides an insight into a new direction of preventing OPM in contrast to conventional viewpoint focusing on the most important factor of area nut chewing.
KW - Community
KW - Erythroleukoplakia
KW - Leukoplakia
KW - Metabolic syndrome
KW - Oral pre-malignancy
KW - Oral submucous fibrosis
KW - Population-based
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=79959686872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959686872&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2011.04.011
DO - 10.1016/j.oraloncology.2011.04.011
M3 - Article
C2 - 21592847
AN - SCOPUS:79959686872
SN - 1368-8375
VL - 47
SP - 625
EP - 630
JO - Oral Oncology
JF - Oral Oncology
IS - 7
ER -
