TY - JOUR
T1 - Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma
T2 - Findings from two prospective cohorts
AU - Berger, Eloise
AU - Delpierre, Cyrille
AU - Hosnijeh, Fatemeh Saberi
AU - Kelly-Irving, Michelle
AU - Portengen, Lutzen
AU - Bergdahl, Ingvar A.
AU - Johansson, Ann Sofie
AU - Krogh, Vittorio
AU - Palli, Domenico
AU - Panico, Salvatore
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Kyrtopoulos, Soterios A.
AU - Vineis, Paolo
AU - Chadeau-Hyam, Marc
AU - Vermeulen, Roel
AU - Castagné, Raphaële
AU - Melin, Beatrice
AU - Lenner, Per
AU - Bendinelli, Benedetta
AU - Botsivali, Maria
AU - Chatziioannou, Aristotelis
AU - Valavanis, Ioannis
AU - Bodinier, Barbara
AU - Garrido-Manriquez, Javiera
AU - Athersuch, Toby J.
AU - Liquet, Benoît
AU - Lokhorst, Henk
AU - Georgiadis, Panagiotis
AU - Kleinjans, Jos C.S.
AU - De Kok, Theo M.C.M.
AU - Keun, Hector C.
AU - Kelly, Rachel
AU - Hallmans, Goran
AU - Stephanou, Euripides G.
AU - Myridakis, Antonis
AU - Kogevinas, Manolis
AU - Fazzo, Lucia
AU - De Santis, Marco
AU - Comba, Pietro
AU - Kiviranta, Hannu
AU - Rantakokko, Panu
AU - Airaksinen, Riikka
AU - Ruokojarvi, Paivi
AU - Gilthorpe, Mark
AU - Fleming, Sarah
AU - Fleming, Thomas
AU - Tu, Yu Kang
AU - Lundh, Thomas
AU - Chien, Kuo Liong
AU - Chen, Wei J.
AU - Lee, Wen Chung
AU - Hsiao, Chuhsing Kate
AU - Kuo, Po Hsiu
AU - Hung, Hung
AU - Liao, Shu Fen
N1 - Funding Information:
The authors wish to thank all the centers that took part in the study and the additional members of the EnviroGenoMarkers Consortium. For further information on the EnviroGenoMarkers Consortium please visit http://www.envirogenomarkers.net/. This work has been carried out as part of the 7th European Framework Programme (FP7) Envirogenomarkers [226756 to S.K.] project. This work was supported by the Institut National du Cancer [SHSESP14-082 to R.C.]. This work was funded by the European Commission as part of the Lifepath project [H2020 grant number 633666]. This work was supported by La Ligue nationale contre le cancer [Equipe Labellisée LIGUE 2017/CD]).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12
Y1 - 2018/12
N2 - Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.
AB - Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.
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U2 - 10.1038/s41598-018-29041-1
DO - 10.1038/s41598-018-29041-1
M3 - Article
C2 - 30018397
AN - SCOPUS:85050189913
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 10805
ER -
