Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: A cross-sectional analysis from I-Lan Longitudinal Aging Study

Chun Chin Chang; Chien Yi Hsu; Ting Yung Chang; Po Hsun Huang; Li Kuo Liu; Liang Kung Chen; Jaw Wen Chen; Shing Jong Lin

doi:10.1038/srep39434

Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: A cross-sectional analysis from I-Lan Longitudinal Aging Study

Chun Chin Chang, Chien Yi Hsu, Ting Yung Chang, Po Hsun Huang, Li Kuo Liu, Liang Kung Chen, Jaw Wen Chen, Shing Jong Lin

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Abstract

Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.

Original language	English
Article number	39434
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep39434
Publication status	Published - Dec 21 2016

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@article{426021ea47144d29a388551b6698110f,

title = "Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: A cross-sectional analysis from I-Lan Longitudinal Aging Study",

abstract = "Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.",

author = "Chang, {Chun Chin} and Hsu, {Chien Yi} and Chang, {Ting Yung} and Huang, {Po Hsun} and Liu, {Li Kuo} and Chen, {Liang Kung} and Chen, {Jaw Wen} and Lin, {Shing Jong}",

note = "Funding Information: This study was supported, in part, by the following research grants: Novel Bioengineering and Technological Approaches to Solve Two Major Health Problems in Taiwan sponsored by the Taiwan Ministry of Science and Technology Academic Excellence Program under Grant Number: MOST 105-2633-B-009-003; a grant from the ministry of Health and Welfare (MOHW 104-TDU-B-211-113-003). The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} The Author(s) 2016.",

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doi = "10.1038/srep39434",

language = "English",

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T1 - Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people

T2 - A cross-sectional analysis from I-Lan Longitudinal Aging Study

AU - Chang, Chun Chin

AU - Hsu, Chien Yi

AU - Chang, Ting Yung

AU - Huang, Po Hsun

AU - Liu, Li Kuo

AU - Chen, Liang Kung

AU - Chen, Jaw Wen

AU - Lin, Shing Jong

N1 - Funding Information: This study was supported, in part, by the following research grants: Novel Bioengineering and Technological Approaches to Solve Two Major Health Problems in Taiwan sponsored by the Taiwan Ministry of Science and Technology Academic Excellence Program under Grant Number: MOST 105-2633-B-009-003; a grant from the ministry of Health and Welfare (MOHW 104-TDU-B-211-113-003). The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © The Author(s) 2016.

PY - 2016/12/21

Y1 - 2016/12/21

N2 - Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.

AB - Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the 'Fried frailty phenotype' criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01-1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.

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Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: A cross-sectional analysis from I-Lan Longitudinal Aging Study

Abstract

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UN SDGs

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