Association between ischemic stroke and iron-deficiency anemia: A population-based study

Yen Liang Chang, Shih Han Hung, Wells Ling, Herng Ching Lin, Hsien-Chang Li, Shiu Dong Chung

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84 Citations (Scopus)


Background: Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan. Methods: The case-control study subjects were obtained from the Taiwanese Longitudinal Health Insurance Database 2000. We included 51,093 subjects with stroke as cases and randomly selected 153,279 controls (3 controls per case) in this study. Separate conditional logistic regression analyses were used to calculate the odds ratio (OR) for having been previously diagnosed with IDA between cases and controls. We further analyzed the association between stroke and IDA by stroke subtype. Results: Results showed that 3,685 study subjects (1.81%) had been diagnosed with IDA prior to the index date; of those subjects, 1,268 (2.48%) were cases and 2,417 (1.58%) were controls (p

Original languageEnglish
Article numbere82952
JournalPLoS ONE
Issue number12
Publication statusPublished - Dec 9 2013

ASJC Scopus subject areas

  • General


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