Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Chun Chin Chang, Chien Yi Hsu, Po Hsun Huang, Li Kuo Liu, Liang-Kung Chen, Jaw Wen J.W. Chen, Shing Jong Lin

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Aim: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. Methods: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50–92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. Results: Overall, 955 participants (53.1%) were non-frail, 724 (40.2%) were pre-frail and 119 (6.7%) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95% CI 1.92–3.33), C-reactive protein (OR 1.19, 95% CI 1.00–1.42), CIMT (OR 1.27, 95% CI 1.04–1.55) and femoral neck BMD (OR 0.49, 95% CI 0.38–0.65) were independently associated with frailty. Conclusions: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449–2454. © 2017 Japan Geriatrics Society
Original languageEnglish
Pages (from-to)2449-2454
Number of pages6
JournalGeriatrics and Gerontology International
Issue number12
Publication statusPublished - 2017


  • atherosclerosis
  • frailty
  • inflammation
  • albumin
  • biological marker
  • C reactive protein
  • creatinine
  • glycosylated hemoglobin
  • somatomedin C
  • adult
  • aged
  • arterial wall thickness
  • Article
  • bone density
  • controlled study
  • cross-sectional study
  • disease association
  • Doppler ultrasonography
  • elderly care
  • female
  • femoral neck
  • human
  • major clinical study
  • male
  • priority journal
  • Taiwan
  • urinary excretion
  • frail elderly
  • middle aged
  • risk factor
  • very elderly
  • Aged
  • Aged, 80 and over
  • Atherosclerosis
  • Biomarkers
  • Bone Density
  • C-Reactive Protein
  • Carotid Intima-Media Thickness
  • Frail Elderly
  • Frailty
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Risk Factors


Dive into the research topics of 'Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population'. Together they form a unique fingerprint.

Cite this