Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers

Kirsten Beyer; Renate Nickel; Linda Freidhoff; Bengt Björkstén; Shau Ku Huang; Kathleen C. Barnes; Susan MacDonald; Johannes Forster; Fred Zepp; Volker Wahn; Terri H. Beaty; David G. Marsh; Ulrich Wahn

doi:10.1046/j.1523-1747.2000.00096.x

Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers

Kirsten Beyer, Renate Nickel, Linda Freidhoff, Bengt Björkstén, Shau Ku Huang, Kathleen C. Barnes, Susan MacDonald, Johannes Forster, Fred Zepp, Volker Wahn, Terri H. Beaty, David G. Marsh, Ulrich Wahn

School of Medical Laboratory Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS '90), parental DNA was tested in 77 of 192 children with atopic dermatitis; (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.

Original language	English
Pages (from-to)	906-908
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	115
Issue number	5
DOIs	https://doi.org/10.1046/j.1523-1747.2000.00096.x
Publication status	Published - 2000

Keywords

Genetics
Marker analysis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1046/j.1523-1747.2000.00096.x

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Beyer, K., Nickel, R., Freidhoff, L., Björkstén, B., Huang, S. K., Barnes, K. C., MacDonald, S., Forster, J., Zepp, F., Wahn, V., Beaty, T. H., Marsh, D. G., & Wahn, U. (2000). Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers. Journal of Investigative Dermatology, 115(5), 906-908. https://doi.org/10.1046/j.1523-1747.2000.00096.x

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title = "Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers",

abstract = "Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS '90), parental DNA was tested in 77 of 192 children with atopic dermatitis; (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.",

keywords = "Genetics, Marker analysis",

author = "Kirsten Beyer and Renate Nickel and Linda Freidhoff and Bengt Bj{\"o}rkst{\'e}n and Huang, {Shau Ku} and Barnes, {Kathleen C.} and Susan MacDonald and Johannes Forster and Fred Zepp and Volker Wahn and Beaty, {Terri H.} and Marsh, {David G.} and Ulrich Wahn",

note = "Funding Information: We thank all families for their generous participation in this study and the physicians, research nurses and technicians for their essential contribution. We especially thank Xie Lun Xue, Xiu Liu, and Eva Ehrlich for excellent technical support. This study was funded by the German Ministry of Research and Technology (BMFT) grant no. 01EE9406, NIH grant AI20059, and by the Vardal Foundation and the National Association for the Prevention of Asthma and Allergies. Kirsten Beyer was supported by BMFT grant no. 01EE9606.",

year = "2000",

doi = "10.1046/j.1523-1747.2000.00096.x",

language = "English",

volume = "115",

pages = "906--908",

journal = "Journal of Investigative Dermatology",

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T1 - Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers

AU - Beyer, Kirsten

AU - Nickel, Renate

AU - Freidhoff, Linda

AU - Björkstén, Bengt

AU - Huang, Shau Ku

AU - Barnes, Kathleen C.

AU - MacDonald, Susan

AU - Forster, Johannes

AU - Zepp, Fred

AU - Wahn, Volker

AU - Beaty, Terri H.

AU - Marsh, David G.

AU - Wahn, Ulrich

N1 - Funding Information: We thank all families for their generous participation in this study and the physicians, research nurses and technicians for their essential contribution. We especially thank Xie Lun Xue, Xiu Liu, and Eva Ehrlich for excellent technical support. This study was funded by the German Ministry of Research and Technology (BMFT) grant no. 01EE9406, NIH grant AI20059, and by the Vardal Foundation and the National Association for the Prevention of Asthma and Allergies. Kirsten Beyer was supported by BMFT grant no. 01EE9606.

PY - 2000

Y1 - 2000

N2 - Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS '90), parental DNA was tested in 77 of 192 children with atopic dermatitis; (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.

AB - Atopic dermatitis is a chronic inflammatory skin disease that affects 10-20% of the population. Linkage of atopy, asthma, allergic rhinitis, and total serum IgE levels to several different chromosomal regions have been described extensively, but little is known about the genetic control of atopic dermatitis. We tested for the association and linkage between atopic dermatitis and five chromosomal regions: 5q31-33, 6p21.3, 12q15-24.1, 13q12-31, and 14q11.2/14q32.1-32.3. Marker analysis was performed in two Caucasian populations: (i) 192 unrelated German children with atopic dermatitis and 59 non-atopic children from a German birth cohort study (MAS '90), parental DNA was tested in 77 of 192 children with atopic dermatitis; (ii) 40 Swedish families with at least one family member with atopic dermatitis selected from the International Study of Asthma and Allergy in Children. Evidence for linkage and allelic association for atopic dermatitis was observed for markers on chromosome 13q12-14 and 5q31-33.

KW - Genetics

KW - Marker analysis

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JF - Journal of Investigative Dermatology

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Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers

Abstract

Keywords

ASJC Scopus subject areas

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