Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

E. W. Loh; S. Higuchi; S. Matsushita; R. Murray; C. K. Chen; D. Ball

doi:10.1038/sj.mp.4000719

Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

E. W. Loh, S. Higuchi, S. Matsushita, R. Murray, C. K. Chen, D. Ball

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)β2, GABA(A)α6, GABA(A)α1 and two at the GABA(A)γ2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)α6 receptor subunit gene and alcohol dependence (P = 0.059). However, the NciI RFLP at the GABA(A)γ2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021). This supports a recent finding reporting an association between the GABA(A)γ2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.

Original language	English
Pages (from-to)	301-307
Number of pages	7
Journal	Molecular Psychiatry
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/sj.mp.4000719
Publication status	Published - 2000
Externally published	Yes

Keywords

Alcoholism
Chromosome 5q33
Dissocial personality disorder

ASJC Scopus subject areas

Molecular Biology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.mp.4000719

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title = "Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population",

abstract = "Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)β2, GABA(A)α6, GABA(A)α1 and two at the GABA(A)γ2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)α6 receptor subunit gene and alcohol dependence (P = 0.059). However, the NciI RFLP at the GABA(A)γ2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021). This supports a recent finding reporting an association between the GABA(A)γ2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.",

keywords = "Alcoholism, Chromosome 5q33, Dissocial personality disorder",

author = "Loh, {E. W.} and S. Higuchi and S. Matsushita and R. Murray and Chen, {C. K.} and D. Ball",

note = "Funding Information: This study was supported by the Peacock Foundation and the Psychiatry Research Trust. We thank Mr Steven Chen, Centec Scientific Inc, Taipei, Taiwan, Republic of China, for providing the notebook computer used to analyse the data in this study.",

year = "2000",

doi = "10.1038/sj.mp.4000719",

language = "English",

volume = "5",

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T1 - Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

AU - Loh, E. W.

AU - Higuchi, S.

AU - Matsushita, S.

AU - Murray, R.

AU - Chen, C. K.

AU - Ball, D.

N1 - Funding Information: This study was supported by the Peacock Foundation and the Psychiatry Research Trust. We thank Mr Steven Chen, Centec Scientific Inc, Taipei, Taiwan, Republic of China, for providing the notebook computer used to analyse the data in this study.

PY - 2000

Y1 - 2000

N2 - Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)β2, GABA(A)α6, GABA(A)α1 and two at the GABA(A)γ2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)α6 receptor subunit gene and alcohol dependence (P = 0.059). However, the NciI RFLP at the GABA(A)γ2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021). This supports a recent finding reporting an association between the GABA(A)γ2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.

AB - Recent investigations suggest that genetic susceptibility to alcohol dependence may be conferred by GABA(A) receptor subunit genes. In this study, three RFLPs at the GABA(A)β2, GABA(A)α6, GABA(A)α1 and two at the GABA(A)γ2 receptor subunit genes, were examined for association with alcohol dependence in 189 subjects meeting DSM-III-R criteria for this disorder and 152 unrelated controls from a Japanese population. The results demonstrated no association between the AlwNI RFLP at the GABA(A)α6 receptor subunit gene and alcohol dependence (P = 0.059). However, the NciI RFLP at the GABA(A)γ2 receptor subunit gene was associated with alcohol dependence comorbid with antisocial personality disorder (P = 0.021). This supports a recent finding reporting an association between the GABA(A)γ2 receptor subunit gene and alcohol dependence with criminal record in a Finnish population. Taking into account the effects of multiple comparisons, this result should be interpreted with caution pending replication.

KW - Alcoholism

KW - Chromosome 5q33

KW - Dissocial personality disorder

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Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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